Article

[Massive hyperoxaluria].

Division de Néphrologie, CHUV, Lausanne.
Revue medicale de la Suisse romande 09/2004; 124(8):477-82. pp.477-82
Source: PubMed

ABSTRACT Primary hyperoxaluria type I is a rare inborn error of metabolism caused by a deficiency of a liver-specific peroxisomal enzyme. It manifests by increased oxalate production that ultimately results in kidney failure, due to urolithiasis and nephrocalcinosis, and finally induces systemic oxalosis and risk of premature death. Primary hyperoxaluria type 2 is mainly responsible of urolithiasis. Enteric hyperoxaluria is a commonly seen adverse event of Crohn disease or after extensive intestinal resection. These affections represent the main etiologies of massive hyperoxaluria. If not recognized very soon and adequately treated, these conditions can progress rapidly to end stage renal failure.

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Keywords

Crohn disease
 
end stage renal failure
 
Enteric hyperoxaluria
 
extensive intestinal resection
 
induces systemic oxalosis
 
kidney failure
 
liver-specific peroxisomal enzyme
 
main etiologies
 
massive hyperoxaluria
 
oxalate production
 
premature death
 
Primary hyperoxaluria type
 
Primary hyperoxaluria type 2
 
rare inborn error
 
seen adverse event