PET technology: current trends and future developments

Royal Victoria Eye and Ear Hospital, Dublin, Leinster, Ireland
British Journal of Radiology (Impact Factor: 2.03). 12/2004; 77(923):906-10. DOI: 10.1259/bjr/32045866
Source: PubMed
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    ABSTRACT: By means of numerical methods, the question is studied of applicability of the inhomogeneity indicator in positron emission tomography. The signal registered by the tomograph is described in terms of an imitation model using the Monte Carlo method. The possibility is demonstrated of the effective use of the inhomogeneity indicator for solving the problem under consideration. Some numerical results are presented in graphical form for reconstructing the boundaries of unknown activity sources.
    Journal of Applied and Industrial Mathematics 04/2012; 6(2). DOI:10.1134/S1990478912020160
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    ABSTRACT: To review recent findings from positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies that investigate the pathophysiology and treatment of schizophrenia, depression, and dementia. We carried out a review of the literature. PET and SPECT studies have provided evidence of dopamine system dysregulation in patients with schizophrenia and variable loss of monoamines in patients with depression. Antipsychotic response has been demonstrated to be associated with blockade of dopamine D2 receptors, and antidepressant response has now been linked to blockade of serotonin transporter receptors. PET and SPECT have been extensively evaluated as diagnostic procedures for dementia. Substantial progress has been made in developing radioligands that bind to amyloid deposits in the brain, which should provide new opportunities for early diagnosis and treatment monitoring in Alzheimer's disease. Advances in PET and SPECT imaging have provided new insights into the biology of major psychiatric disorders and their treatment. In the future, we can expect that these imaging techniques will become more central to the management of psychiatric disorders.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie 04/2007; 52(3):146-57. · 2.55 Impact Factor
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    ABSTRACT: For positron emission tomography scanners requiring 511 keV two-photon detection, we present a charge-sensitive amplifier (CSA) to be associated with an avalanche photodiode (APD) or photo-multiplier tube (PMT). It is a two-stage structure. The input stage consists of a folded-cascode fully differential circuit and a common-mode feedback (CMFB) circuit. Feedforward technique is implemented to enhance frequency performance. The output stage employs complementary source followers. The amplifier has been designed in a 0.35-μm BiCMOS process with analysis and optimization of noise and speed performances. Testing of fabricated prototypes has given results in good agreement with post-layout simulated ones. The evaluated characteristics of the circuit are: 26 ns peaking time for pulsed stimulus, 2000 electron equivalent input noise charge (ENC) for a detector capacitance up to 80 pF and 136 mW power consumption from a 3.5-V supply.
    Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 01/2010; 613(1-613):134-140. DOI:10.1016/j.nima.2009.11.063 · 1.22 Impact Factor
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