Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.
ABSTRACT Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.
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ABSTRACT: Malaria is a major international public health problem. Drug-resistant parasites have made treatment and control of malaria more difficult. Therefore, safe, affordable and effective new drugs are urgently needed. Traditional medicine is an important source for new drugs. Determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms like malaria. Then the plants that used to treat "Ghebbe Khalesseh fever" were listed. Finally, recent antimalarial researches were explored. About 31 plants were identified. Information from these resources is valuable for the selection of plants for antiplasmodial screening programs.Iranian Journal of Parasitology 10/2014; 9(4):553-9. · 0.87 Impact Factor
Article: Suntar, I., Akkol, K., Keles, H., Yesilada, E., Sarker, S. D. and Baykal, T. (2012) Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: Stepwise isolation of an active component by in vivo bioassay and its mode of activity, J. Ethnopharmacology 143, 299-309 (IF 3.728).Journal of Ethnopharmacology 04/2012; 143:299-309. · 2.94 Impact Factor
Chapter: CichorieaeSystematics, evolution and biogeography of Compositae, Edited by Funk V. A., Susanna A., Stuessy T. E. & Bayer R. J., 01/2009: chapter Cichorieae.: pages 343-383; IAPT., ISBN: 978-3-9501754-3-1