Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.
ABSTRACT Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.
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ABSTRACT: The use of natural products as medicinal agents presumably predates the earliest recorded history. Cichorium Intybus L. is a plant which is used in several traditional medicine systems to cure various diseases Chicory belongs to the family Asteraceae is a small aromatic biennial or perennial herb. This plant has been known to posses Anti-ulcer, Hepatoprotective, Antibacterial, Cardioprotective, Antioxidant and Free radical Scavenging, Anti-malarial, Anti-fungal, Gastroprotective, Antihelminthic, Analgesics, Tumour protective, Anti-allergic and other miscellaneous activities. The whole plant contains a number of medicinally important compounds showing therapeutic effects such as inulin, esculin, volatile compounds, bitter sesquiterpene lactones, coumarins, flavonoids and vitamins etc. The pharmacological studies reported in the present review confirm the therapeutic value of Chichorium Intybus L. Thus the use of this plant for human and animal disease therapy and reinforce the importance of the ethno-botanical approach as a potential source of bioactive substances.
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ABSTRACT: Malaria is a major international public health problem. Drug-resistant parasites have made treatment and control of malaria more difficult. Therefore, safe, affordable and effective new drugs are urgently needed. Traditional medicine is an important source for new drugs. Determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms like malaria. Then the plants that used to treat "Ghebbe Khalesseh fever" were listed. Finally, recent antimalarial researches were explored. About 31 plants were identified. Information from these resources is valuable for the selection of plants for antiplasmodial screening programs.Iranian Journal of Parasitology 10/2014; 9(4):553-9. · 0.87 Impact Factor