Article

Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

Department of Pharmacy, Massachusetts General Hospital, Boston, MA 02114, USA.
Journal of Ethnopharmacology (Impact Factor: 2.94). 01/2005; 95(2-3):455-7. DOI: 10.1016/j.jep.2004.06.031
Source: PubMed

ABSTRACT Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.

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