Anti-inflammatory and anti-nociceptive activity of the water decoction Desmodium gangeticum.
ABSTRACT The water decoction of root and aerial parts of Desmodium gangeticum (Leguminosae) was examined for anti-inflammatory and anti-nociceptive activity in experimental animals. The root and aerial decoction in doses of 5, 10 and 20 mg /kg caused a dose-dependent inhibition of swelling caused by carrageenin equivalent to 14.58-51.02% protection and 14.43-38.67%, respectively, in cotton pellet granuloma. There was a significant increase in analgesio-meter-induced force equivalent to 6.56-67.66% protection and 22.18-73.83% protection in acetic acid-induced writhing. The result establishes the traditional use of water decoction of Desmodium gangeticum codified in Indian System of Medicine.
- SourceAvailable from: Pallavi Nirmal[Show abstract] [Hide abstract]
ABSTRACT: Dashamoola is a polyherbal preparation derived from roots of ten plants. It is used in Indian traditional medicine for different ailments especially for inflammation using various dosage forms. The objective of this study was to evaluate antioxidant and anti-inflammatory activity of selected dosage forms of Dashamoola. Dosage forms viz. Arishta of Dashamoola where as Churna, Kalpa and Kwatha of Dashamoola, Brihatpanchamoola and Laghupanchamoola were investigated. Antioxidant activity was assayed by using DPPH free radical scavenging activity, total antioxidant activity by FRAP, anti-lipid peroxidation activity and nitric oxide scavenging potential whereas anti-inflammatory potential was checked by Carrageenan induced rat paw edema model. Dashamoola Kwatha (341.92±10.36 µg/ml), Brihatpanchamoola Kwatha (1754.26±299.87 µg/ml), Dashamoola Churna (149.24±61.09 µg/ml) exhibited highest activity with lowest IC50 values for free radical scavenging, anti-lipid peroxidation and nitric oxide scavenging respectively. Laghupanchamoola Kwatha showed highest concentration of antioxidants (0.278±0.003 µg/ml) and thereby exhibited highest total antioxidant activity. In case of carrageenan induced rat paw edema model, Dashamoola Kwatha at a dose of 1.8 ml/kg bw produced the significant reduction in paw edema (44.29%) followed by Dashamoolarishta (43.35%) at a dose of 0.9 ml/kg bw. Almost all selected dosage forms of Dashamoola displayed antioxidant as well as anti-inflammatory activity at different levels. Dashamoola Kwatha and Dashamoolarishta showed consistent and significant results. The results of present investigation suggest that Kwatha and Arishta are the most suitable dosage forms of Dashamoola for the treatment of inflammatory disorders. These findings also support the traditional use of specific dosage forms of drug.World Journal of Pharmacy and Pharmaceutical Sciences. 09/2013; 2(5):3118-3136.
- [Show abstract] [Hide abstract]
ABSTRACT: D-pinitol (3-O-methyl-D-inositol), a form of vitamin B inositol is a sugar-like molecule used for natural healing purposes for various diabetic-associated conditions. It is found in various plants like legumes, leafy vegetables, and citrus fruits, but is not found in animals and humans. In the present investigation, we have predicted possible biological molecular targets for D-pinitol using reverse docking approaches. In the process, we have identified that D-pinitol have affinity for most of the enzymes directly/indirectly associated with the free radical scavenging processes, indicating that D-pinitol might use as a potential antioxidant. The prediction was further in vivo validated on C. elegans, a multicellular model system using chemotaxis, thermo-tolerance and ROS scavenging activities assay. A strong correlation was observed in the computational prediction and in vivo antioxidant activities assays of D-pinitol in a dose-dependent manner. The findings broaden our current perspectives in understanding the antioxidative properties of D-pinitol.International journal of computer application. 10/2013; (NSAAILS - 2013):0975 – 8887.
- [Show abstract] [Hide abstract]
ABSTRACT: Dashamoolarishta, a well known polyherbal formulation used for different ailments especially for inflammation and need clnical validation of its efficacy in cervicitis wich is important but neglected disorder. Present research work was carried out with the aim to evaluate the efficacy of Dashamoolarishta on cervicitis. Study was conducted in perimenopausal patients to assess the efficacy of trial drug "Dashamoolarishta". Total of 30 perimenopausal patients were selected for the study after screening 113 patients. Out of them, 30 patients completed the study. The trial drug Dashamoolarishta was given in the dose of 20 ml BD for 90 days with water and follow up was conducted after every 15 days. The study revealed the statistically significant decrease in cervical redness, swelling, low backache. Significant inflammatory changes were observed in pap smear test. ESR was significantly decreased after treatment. Dashamoolarishta is a potential drug for cervicitis.Journal of Pharmacy and Pharmaceutical Sciences 05/2014; 3(6). · 2.20 Impact Factor