Anti-inflammatory and anti-nociceptive activity of the water decoction Desmodium gangeticum

Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (Council of Scientific and Industrial Research), Rana Pratap Marg, Post Box No. 436, Lucknow 226 001, Uttar Pradesh, India.
Journal of Ethnopharmacology (Impact Factor: 2.94). 01/2005; 95(2-3):259-63. DOI: 10.1016/j.jep.2004.07.009
Source: PubMed

ABSTRACT The water decoction of root and aerial parts of Desmodium gangeticum (Leguminosae) was examined for anti-inflammatory and anti-nociceptive activity in experimental animals. The root and aerial decoction in doses of 5, 10 and 20 mg /kg caused a dose-dependent inhibition of swelling caused by carrageenin equivalent to 14.58-51.02% protection and 14.43-38.67%, respectively, in cotton pellet granuloma. There was a significant increase in analgesio-meter-induced force equivalent to 6.56-67.66% protection and 22.18-73.83% protection in acetic acid-induced writhing. The result establishes the traditional use of water decoction of Desmodium gangeticum codified in Indian System of Medicine.

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