Article

Distribution patterns of trace metals and of lipid peroxidation in plasma and erythrocytes of rat exposed to aluminum.

Department of Food and Nutrition, Hung Kuang University, Taichung 433, Taiwan, Republic of China.
Biological Trace Element Research (impact factor: 1.92). 11/2004; 101(1):61-71. DOI:10.1385/BTER:101:1:61 pp.61-71
Source: PubMed

ABSTRACT Significant decreases of the hematocrit, hemoglobin, and plasma iron levels were observed in rats receiving daily intraperitoneal injections of aluminum at a dose of 27 mg Al/kg body wt for 3 wk, as compared to untreated controls. The activity of alkaline phosphatase was also significantly lower in the treated animals as a result of the accumulation of aluminum in the liver (p<0.05). Following aluminum administration, the plasma concentrations of aluminum and copper were also significantly increased, whereas the plasma zinc levels and oxidative stress measured through thiobarbituric acid reaction products showed nonsignificant differences between the two groups (p>0.05). The erythrocyte concentrations of aluminum, copper, zinc, and iron and of superoxide dismutase activity were found to be significantly higher in the study group as compared to controls. The treated animals also showed evidence of higher oxidative stress in comparison to controls. These results suggest that erythrocyte aluminum accumulation could result in abnormal trace element homeostasis and increasing oxidative stress, which might be a mechanism of aluminum-induced anemia.

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Keywords

27 mg Al/kg body wt
 
abnormal trace element homeostasis
 
aluminum administration
 
aluminum-induced anemia
 
erythrocyte aluminum accumulation
 
erythrocyte concentrations
 
higher oxidative stress
 
intraperitoneal injections
 
nonsignificant differences
 
oxidative stress
 
plasma concentrations
 
plasma iron levels
 
plasma zinc levels
 
Significant decreases
 
superoxide dismutase activity
 
thiobarbituric acid reaction products
 
treated animals
 
two groups
 
untreated controls
 
zinc