Article

Modulation of Th1 and Th2 cytokine profiles and their association with advanced head and neck squamous cell carcinoma.

Department of Otorhinolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19107, USA.
Otolaryngology Head and Neck Surgery (impact factor: 1.72). 12/2004; 131(5):573-6. DOI:10.1016/j.otohns.2004.03.016
Source: PubMed

ABSTRACT Plasma cytokine concentrations from patients with head and neck squamous cell carcinoma (HNSCC) were measured to determine whether the potential modulation of host Th1 vs Th2 immune responses are associated with advanced clinical disease.
The concentrations of IL-4, IL-6, IL-10, and IL-12 were measured in the plasma of 58 patients with histologically proven HNSCC. These data were examined with respect to the histologic size (T-stage) of the primary tumor, and presence of nodal metastasis.
The concentrations of IL-12 were greater from patients without nodal metastasis, and with T(1)/T(2)-stage tumors. IL-10 levels were greater from patients with nodal metastasis, and with T(3)/T(4)-stage tumors. The concentrations of IL-6 were greater from patients with T(3)/T(4)-stage tumors.
Using parameters of primary tumor size and presence of nodal metastasis, patients with advanced HNSCC have significantly less plasma IL-12 levels, and greater plasma IL-10 and IL-6 levels.
Patients with advanced HNSCC have a potentially diminished Th1 immune response, and a stronger potential Th2 immune response when compared to that of patients with less advanced disease. EBM rating: D-5.

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Keywords

58 patients
 
advanced disease
 
clinical disease
 
diminished Th1 immune response
 
EBM rating
 
greater plasma IL-10
 
HNSCC
 
host Th1
 
IL-6
 
IL-6 levels
 
nodal metastasis
 
Patients
 
plasma
 
Plasma cytokine concentrations
 
plasma IL-12 levels
 
potential modulation
 
primary tumor
 
primary tumor size
 
stronger potential Th2 immune response
 
Th2 immune responses
 

Anthony Sparano