Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line

Division of Biochemistry and Molecular Biology, Kyoto Prefectural University of Medicine, Kioto, Kyōto, Japan
FEBS Letters (Impact Factor: 3.34). 12/2004; 577(1-2):55-9. DOI: 10.1016/j.febslet.2004.09.085
Source: PubMed

ABSTRACT Genistein is the most abundant isoflavone of soybeans and has been shown to cause growth arrest in various human cancer cell lines. However, the precise mechanism for this is still unclear. We report here that the growth arrest and DNA damage-inducible gene 45 (gadd45) gene is induced by genistein via its promoter in a DU145 human prostate cancer cell line. The binding of transcription factor nuclear factor-Y to the CCAAT site of the gadd45 promoter appears to be important for this activation by genistein.

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Available from: Yoshihiro Sowa, Jul 26, 2015
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    • "Genistein contributes to apoptosis and inhibits proliferation via promotion of antioxidant enzyme activities in prostate cancer cells of LNCaP and PC-3 [2], as well as DU-145 [3]. Genistein may also modulate correlative gene expression to promote cancer cell apoptosis through the influence of growth arrest and DNA damage-inducible gene 45 (Gad45) in DU-145 [4]. The mechanism of action of genistein is complex and includes several cellular pathways . "
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