The MATRICS initiative: Developing a consensus cognitive battery for clinical trials
Schizophrenia Research (Impact Factor: 3.92). 01/2005; 72(1):1-3. DOI: 10.1016/j.schres.2004.09.006
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- "Neuropsychological assessment A comprehensive neuropsychological test battery was administered to all participants. Cognitive tests scores were reduced to the following six cognitive domains of the MATRICS consensus battery (Green et al., 2004): speed of processing, working memory, verbal learning and memory, visual learning and memory, attention/vigilance , reasoning, and problem solving. The appropriateness of the six factor structures was validated in a previous study (Noh et al., 2010). "
ABSTRACT: The neuregulin 1 (NRG1) gene has been investigated as a candidate susceptibility gene for schizophrenia. A number of studies have also explored the genetic effect of NRG1 on cognitive deficits related to schizophrenia, and thus far generated inconsistent results. The current study aimed to determine whether genetic variations in NRG1 are associated with cognitive domains in schizophrenic patients and healthy individuals. Comprehensive neuropsychological tests composed of six cognitive domains were administered to 135 clinically stable patients with schizophrenia and 119 healthy individuals. On the basis of previous reports of positive association, a total of four single nucleotide polymorphisms were analyzed. In testing the genotype effect on cognitive domains, we used repeated-measure analysis for six cognitive domain scores of each individual as repeated measurements. An association of P-value less than 0.05 with at least one cognitive domain in patients and/or healthy individuals was observed for all of the single nucleotide polymorphisms. After applying the correction for multiple testing, the association remained statistically significant between rs6994992 and general cognitive ability (g) in the patient group and between rs2439272 and the 'working memory' domain in the group of healthy participants. This study suggests the involvement of NRG1 in the susceptibility for developing cognitive deficits in schizophrenic patients. For some cognitive domains, its genetic effect was also significant in generating interindividual variability within the normal functional range.Schizophrenia Research 04/2014; 153(4):S237. DOI:10.1016/S0920-9964(14)70680-2 · 3.92 Impact Factor
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- "To support the development of pharmacological agents to improve neurocognitive deficits of schizophrenia, NIMH launched an initiative called “Measurement and Treatment Research to Improve Cognition in Schizophrenia” (MATRICS). As a result this initiative developed a consensus neurocognitive battery for use in clinical trials to study the pharmacological effects on neurocognition (Green and Nuechterlein, 2004). "
ABSTRACT: Brain-Derived Neurotrophic Factor (BDNF) is a neurotrophin that has been related not only to neurodevelopment and neuroprotection, but also to synapse regulation, learning, and memory. Research focused on the neurobiology of schizophrenia has emphasized the relevance of neurodevelopmental and neurotoxicity-related elements in the pathogenesis of this disease. Research focused on the clinical features of schizophrenia in the past decades has emphasized the relevance of cognitive deficits of this illness, considered a core manifestation and an important predictor for functional outcome. Variations in neurotrophins such as BDNF may have a role as part of the molecular mechanisms underlying these processes, from the neurodevelopmental alterations to the molecular mechanisms of cognitive dysfunction in schizophrenia patients.Frontiers in Psychiatry 06/2013; 4:45. DOI:10.3389/fpsyt.2013.00045
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- "During the high visual demand condition, subjects were required to perform a visual Continuous Performance Test — Identical Pairs version (CPT-IP; Comblatt et al., 1988) and told to ignore the auditory stimuli. The CPT-IP is considered a gold standard neurocognitive measure of vigilance functioning as determined by an expert consensus panel convened for the Measurement and Treatment Research to Improve Cognition in Schizophrenia initiative (Green and Nuechterlein, 2004). Prior to testing and EEG recording, standardized instructions and a block of practice CPT-IP trials were administered to ensure that participants understood the instructions and would perform the CPT-IP task appropriately. "
ABSTRACT: Background: Mismatch negativity (MNN) and P3a are event related potential (ERP) measures of early sensory information processing. These components are usually conceptualized as being "pre-attentive" and therefore immune to changes with variations in attentional functioning. This study aimed to determine whether manipulations of attention influence the amplitudes and latencies of MMN and P3a and, if so, the extent to which these early sensory processes govern concurrent behavioral vigilance performance in schizophrenia patients and normal subjects. Methods: Schizophrenia patients (SZ; n = 20) and Nonpsychiatric Control Subjects (NCS; n = 20) underwent auditory ERP testing to assess MMN and P3a across 4 EEG recording sessions in which attentional demand (low vs. high) and sensory modality of directed attention (visual vs. auditory) were experimentally varied. Results: Across conditions, SZ patients exhibited deficits in MMN and P3a amplitudes. Significant amplitude and latency modulation were observed in both SZ and NCS but there were no group-by-condition interactions. The amount of MMN amplitude attenuation from low- to high-demand tasks was significantly associated with increased vigilance performance in both SZ and NCS groups (r = -0.67 and r = -0.60). Several other robust associations were also observed among neurophysiologic, clinical and cognitive variables. Conclusions: Attentional demand and modality of directed attention significantly influence the amplitude and latencies of "pre-attentive" ERP components in both SZ and NCS. Deficits in MMN and P3a were not "normalized" when attention was directed to the auditory stimuli in schizophrenia patients. The adaptive modulation of early sensory information processing appears to govern concurrent attentional task performance. The temporal window reflecting automatic sensory discrimination as indexed as MMN and P3a may serve as a gateway to some higher order cognitive operations necessary for psychosocial functioning.Schizophrenia Research 03/2013; 146(1-3). DOI:10.1016/j.schres.2013.01.035 · 3.92 Impact Factor
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