Article

Infrequent reinfection after successful treatment for hepatitis C virus infection in injection drug users

Cornell University, Итак, New York, United States
Clinical Infectious Diseases (Impact Factor: 9.42). 12/2004; 39(10):1540-3. DOI: 10.1086/425361
Source: PubMed

ABSTRACT We followed-up 18 injection drug users for a mean of 33.8 months (range, 4-55 months) after successful treatment for hepatitis C virus (HCV) infection. Fifteen (83%) of the patients remained HCV RNA-negative, 1 patient was not tested, and 2 patients had test results positive for HCV RNA. The estimated rate of reinfection as a result of injection drug use was 0-4.1 cases per 100 person-years (cumulative incidence, 0%-12.6% at 48 months after completion of treatment). Of 50 patients originally treated, 15 (30%) were HCV RNA-negative 3 years later.

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    • "The number of new infections per year is therefore given by so that per year. There is debate about the rate of reinfection in those that have previously cleared infection with estimates ranging from 2% to 47% per year (Aitken et al., 2008a; Backmund et al., 2004; Grebely et al., 2006). We assume a reinfection rate, of 5% per year thus but acknowledge that new research suggests it is higher than this. "
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    • "Unstable accommodation and lack of safe, refrigerated facilities for HCV therapies; limited or cost-prohibitive transportation options; and conflict with the law (Cooper & Mills, 2006; Fischer et al., 2004; Strathdee et al., 2005) also present as potential barriers. Despite these barriers, recent evidence suggests that IDUs can be treated effectively for HCV infection, particularly when treatment programs involve a multidisciplinary team (Backmund, Meyer, Von Zielonka, & Eichenlaub, 2001; Backmund et al., 2004; Crofts, Jolley, Kaldor, van Beek, & Wodak, 1997; Matthews et al., 2005; Sylvestre, 2005), which manage patients on a case-by-case basis (Edlin, 2002; Fischer et al., 2004). Unlike chronic HCV infection, high treatment responses for acute HCV infection are obtained with interferon monotherapy, including more recently with pegylatedinterferon (PEG-IFN) (Jaeckel et al., 2001; Kamal et al., 2004, 2006; Wiegand et al., 2006). "
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