Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20: 2580-2590

Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA.
European Journal of Neuroscience (Impact Factor: 3.18). 12/2004; 20(10):2580-90. DOI: 10.1111/j.1460-9568.2004.03720.x
Source: PubMed


We found that a short exercise period enhanced cognitive function on the Morris water maze (MWM), such that exercised animals were significantly better than sedentary controls at learning and recalling the location of the platform. The finding that exercise increased brain-derived neurotrophic factor (BDNF), a molecule important for synaptic plasticity and learning and memory, impelled us to examine whether a BDNF-mediated mechanism subserves the capacity of exercise to improve hippocampal-dependent learning. A specific immunoadhesin chimera (TrkB-IgG), that mimics the BDNF receptor, TrkB, to selectively bind BDNF molecules, was used to block BDNF in the hippocampus during a 1-week voluntary exercise period. After this, a 2-trial-per-day MWM was performed for 5 consecutive days, succeeded by a probe trial 2 days later. By inhibiting BDNF action we blocked the benefit of exercise on cognitive function, such that the learning and recall abilities of exercising animals receiving the BDNF blocker were reduced to sedentary control levels. Inhibiting BDNF action also blocked the effect of exercise on downstream systems regulated by BDNF and important for synaptic plasticity, cAMP response-element-binding protein (CREB) and synapsin I. Specific to exercise, we found an association between CREB and BDNF expression and cognitive function, such that animals who were the fastest learners and had the best recall showed the highest expression of BDNF and associated CREB mRNA levels. These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism.

1 Follower
16 Reads
  • Source
    • "These studies demonstrated that the benefits of exercise at the cellular level likely due to its ability to increase the production of BDNF and other signaling molecules in sleep-deprived male (Zagaar et al., 2012) and female (Saadati et al., 2014a) rats. Hippocampal BDNF can mediate the effect of exercise on cognitive functions (Vaynman et al., 2004). Therefore physical exercise could prevent the decreasing effect of SD in the OVX female rats.Of course we did not focus on the role of signaling molecule in the present study. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Previous studies have been shown that exercise can improve short-term spatial learning, memory and synaptic plasticity impairments in sleep deprived female rats. The aim of the present study was to investigate the effects of treadmill exercise on sleep deprivation (SD) induced impairment in hippocampal dependent long-term memory in female rats. Intact and ovariectomized female rats were used in the current study. Exercise protocol was 4 weeks treadmill running. Twenty four hour SD was induced by using multiple platform apparatus after learning phase. Spatial learning and long-term memory was examined by using the Morris Water Maze (MWM) test. Our results indicated that sleep deprivation impaired long term memory in the intact and ovariectomized female rats, regardless of reproductive status (p<0.05) and treadmill exercise compensated this impairment (p<0.05). In conclusion the results of the current study confirmed the negative effect of SD on cognitive functions and regular exercise seems to protect rats from these factors, however more investigations need to be done. Copyright © 2015. Published by Elsevier B.V.
    Behavioural processes 07/2015; 119. DOI:10.1016/j.beproc.2015.06.014 · 1.57 Impact Factor
  • Source
    • "The inhibitory effect of ifenprodil on the protective actions of ATV on BDNF levels was verified in the somatosensory cerebral cortex and hippocampus of ischemic rats. BDNF induces motor recovery (Ploughman et al., 2009; Ke et al., 2011), and it is also involved in the regulation of neurogenesis and synaptogenesis (Vaynman et al., 2004; Ploughman et al., 2009). Therefore, BDNF might mediate the protective action of ATV in the brain of ischemic animals, reducing motor, spatial-learning, and memory deficits. "
  • Source
    • "In older humans, levels of aerobic fitness correlate with hippocampal volume (Erickson et al., 2012), and one intriguing study shows that increased levels of BDNF associated with exercise improved rodent's performance in the Morris Water Maze (Vaynman et al., 2004), suggesting that the effect of the exercise improved context-dependent learning. "
    The Preservation of Memory: Theory and Practice for Clinical and Non-Clinical Populations, Edited by Bruno D, 01/2015: chapter The effects of ageing and exercise on recollection and familiarity based memory processes.; Psychology Press: Taylor and Francis..
Show more


16 Reads
Available from