Article

Synthetic studies on the taxane skeleton: construction of eight-membered carbocyclic rings by the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction.

Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Organic Letters (impact factor: 5.86). 12/2004; 6(24):4491-4. DOI:10.1021/ol0481939 pp.4491-4
Source: PubMed

ABSTRACT Construction of eight-membered carbocyclic rings via the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction has been studied. This protocol proved its potency through the formation of the eight-membered ring possessing a quaternary carbon on its ring in high yield, affording promise of a new access to the eight-membered ring of Taxol. [reaction: see text]

0 0
 · 
0 Bookmarks
 · 
39 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

[reaction
 
affording promise
 
eight-membered carbocyclic rings
 
intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction
 
new access
 
potency
 
quaternary carbon
 

Hatsuo Kawada