A new cytotoxic phenylbutenoid dimer from the rhizomes of Zingiber cassumunar
ABSTRACT A new phenylbutenoid dimer, (+/-)- trans-3-(4-hydroxy-3-methoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, was isolated from the rhizomes of Zingiber cassumunar along with the three known compounds, (+/-)- trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, 4-(3,4-dimethoxyphenyl)but-1,3-diene, and 4-(2,4,5-trimethoxyphenyl)but-1,3-diene by bioassay-directed fractionation using the A549 human cancer cell line cytotoxicity assay. Structure of the new compound was elucidated by spectral analysis, including 1D and 2D NMR experiments.
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ABSTRACT: Epitaxially twinned (028)-oriented Bi3.25La0.75Ti3O12 (BLT) thin films were grown on GaN(002)/Al2O3 (0006) substrates by pulsed laser deposition. The BLT layer deposited on GaN substrate showed sixfold-like symmetric peaks in a φ scan of (006) reflection and 12 peaks in that of the (117) reflection. In order to investigate hetero-epitaxial growth, origin of six and 12 peaks in the φ scan, and the domain structure of the BLT thin film, the X-ray analysis including θ–2θ, ω, φ scan, and pole figure measurement were performed. The hetero-epitaxial growth was studied by atomic arrangements and domain distribution with calculated lattice mismatch, interplanar angles, and atomic distances.Journal of Crystal Growth 10/2004; 271(1):50-54. DOI:10.1016/j.jcrysgro.2004.07.020 · 1.69 Impact Factor
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ABSTRACT: Phenylbutenoids isolated previously from the CHCl3 extracts of the rhizomes of Zingiber cassumunar, were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity along with a new isolate, from the n-BuOH extracts of this plant. The COX-2 inhibitory assay was performed by measuring prostaglandin E2 production in lipopolysaccharide-stimulated mouse macrophage RAW 264.7 cells. Two phenylbutenoid dimers, and, exhibited considerable activity with IC50 values of 2.71 and 3.64 microM. Two phenylbutenoid monomers, and, showed moderate activity (IC50 14.97, 20.68 microM, respectively). The other three phenylbutenoids, were found to be inactive. Compound was elucidated as a new phenylbutenoid glycoside, namely, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-O-beta-D-glucopyranoside by spectral analysis including various 1D- and 2D-NMR experiments.CHEMICAL & PHARMACEUTICAL BULLETIN 12/2005; 53(11):1466-8. DOI:10.1248/cpb.53.1466 · 1.38 Impact Factor
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ABSTRACT: While effective treatments exist for acute lymphocytic leukemia (ALL), particularly in the case of children, and for chronic mylogenous leukemia (CML), more efficacious treatments for other forms of acute and chronic forms of the disease are still needed. The National Cancer Institute has tested over 90,000 extracts of terrestrial plants and marine plants and invertebrates in its human cancer one-dose/60-cell-line prescreen, and the results for plants and marine organisms meeting criteria established for activity against selected leukemia cell lines are presented. Taxonomic data are limited to family and genus in the case of plants, and phylum for marine organisms, and those groups of organisms exhibiting significant activity (so-called "hot" families and genera) are discussed. The "hot" terrestrial plant families Myrsinaceae and Sapindaceae have not been studied to any extent and appear to merit special attention, although leukemia cell line selectivity is also noted for other families.Journal of Natural Products 04/2006; 69(3):488-98. DOI:10.1021/np0581216 · 3.95 Impact Factor