Article

Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine.

Center for Clinical Research, Ullevaal University Hospital, NO-0407 Oslo, Norway.
Metabolism (Impact Factor: 3.61). 12/2004; 53(12):1574-9. DOI: 10.1016/j.metabol.2004.06.026
Source: PubMed

ABSTRACT We investigated the levels of asymmetric dimethylarginine (ADMA), an important endogenous inhibitor of nitric oxide (NO), as related to metabolic risk factors known to contribute to atherosclerotic disease. Dimethylarginines were analysed in a cross-sectional study of 563 elderly high-risk men (70 +/- 6 years). ADMA and the l-arginine/ADMA (l-arg/ADMA) ratio were highly significantly correlated with several metabolic risk factors. However, only the association with body mass index (BMI) remained significant after adjustment for inter-related variables. When analyzing the results according to being overweight or not, ADMA levels were independently significantly higher (P = .05) and the L-arg/ADMA ratios were significantly lower (P < .008) in individuals with high BMI (> or =26 kg/m(2), median value) as compared with subjects with low BMI. ADMA levels were furthermore significantly lower (P = .037) and L-arginine and the l-arg/ADMA ratios were significantly higher (P = .004 and P = .001, respectively) in smokers compared with nonsmokers, the latter being independent of other risk factors. The strong relationship found between BMI and plasma levels of ADMA and the l-arg/ADMA ratio indicate a link to endothelial dysfunction in overweight subjects. The beneficial dimethylarginine profile observed in smokers in this elderly population is not easily explainable and should be further investigated.

1 Follower
 · 
95 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aerobic exercise has a beneficial effect on cardiovascular disease. However, the relationship between ADMA and aerobic fitness is unknown. The aim of this study was to determine whether plasma ADMA concentrations correlate with aerobic fitness levels in postmenopausal women. Thirty healthy postmenopausal women aged 50-76 years participated in this study. We measured plasma concentrations of ADMA and oxygen consumption at the ventilatory threshold (VO2VT) as an index of aerobic fitness. Subjects were divided into the low aerobic fitness (Low fitness) and high aerobic fitness (High fitness) groups, and the dividing line was set at the median VO2VT value. VO2VT was significantly higher in the High fitness group than in the Low fitness group (P<0.01). The plasma ADMA concentrations in the High fitness group were significantly lower than those in the Low fitness group (P<0.05). There was a negative correlation between plasma ADMA concentrations and VO2VT (r=-0.532, P<0.01). We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations.
    Life sciences 05/2014; DOI:10.1016/j.lfs.2014.05.003 · 2.30 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose We sought, for the first time, to examine the rate and predictors of hospital readmission in patients discharged after an episode of HF in Nigeria. Methods This was a hospital-based, prospective, observational study that used the data from the Abeokuta HF Registry. Findings Overall, 1.53% (95% CI, 0.58-4.02) and 12.2% (95%CI, 8.88-16.8) of patients, respectively, were re-hospitalized at least once within 30 days and 6 months (5.3% had multiple readmissions); the latter comprising 21/138 men (15.2%) and 11/124 (8.9%) women. A total of 11 (4.2%) also died (all of whom had been re-hospitalized). Worsening HF (24 cases, 75%) was the commonest reason for readmission. Among others, factors associated with rehospitalization include presence of mitral regurgitation (OR, 2.37; 95%CI, 1.26-4.46), age ≥ 60 years (OR, 2.04; 95%CI, 0.96-3.29), presence of tricuspid regurgitation (OR, 1.77; 95% CI, 0.86-3.61), and presence of atrial fibrillation (OR, 1.34; 95%CI, 0.59-3.03). However, on an adjusted basis, only female gender (adjusted OR 0.33, 95% CI 0.14-0.79; p=0.014 versus men) and body mass index <19kg/m2 (adjusted OR 3.74, 95% CI 1.15-12.16; p=0.028 versus rest) were independent correlates of readmission during 6-months follow-up. Conclusions HF rehospitalization within 6-months follow-up occurs in about 12% of our cohort living an environment where HF etiology is predominately non-ischemic and the HF population is relatively younger. Higher rates of readmission were noted in those of older age, lower BMI, low literacy, lower serum sodium level, presence of atrial fibrillation, renal dysfunction and valvular dysfunction.
    Journal of Cardiac Failure 11/2014; 20(11). DOI:10.1016/j.cardfail.2014.08.012 · 3.07 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Asthma is a complex syndrome that affects an estimated 26 million people in the United States but gaps exist in the recognition and management of asthmatic subgroups. This article proposes alternative approaches for future treatments of adult obese asthmatics who do not respond to standard controller therapies, drawing parallels between seemingly disparate therapeutics through their common signaling pathways. How metformin and statins can potentially improve airway inflammation is described and supplements are suggested. A move toward more targeted therapies for asthma subgroups is needed. These therapies address asthma and the comorbidities that accompany obesity and metabolic syndrome to provide the greatest therapeutic potential.
    Immunology and Allergy Clinics of North America 11/2014; 34(4). DOI:10.1016/j.iac.2014.07.006 · 2.22 Impact Factor