Estrogenic and Anticarcinogenic Properties of Kurarinone, a Lavandulyl Flavanone from the Roots of Sophora f lavescens

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
Journal of Natural Products (Impact Factor: 3.8). 12/2004; 67(11):1829-32. DOI: 10.1021/np040069a
Source: PubMed


Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.

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    • "Natural extracts of S. flavescens include a volatile flavonoid component (Kuroyanagi et al. 1999). Previous studies have shown that the major antimicrobial components of S. flavescens are kurarinone, kuraridin, and sophoraflavanone G (De Naeyer et al. 2004; Piao et al. 2006; Han et al. 2007), and antimicrobial activity is related to the quantities of these three major components (Chong et al. 2013). However, this chemical composition can be altered by environmental factors, particularly by temper- ature. "
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    • "In particular, prenylated flavonoids in higher plants protect them by exhibiting strong antibacterial and antifungal activities (Sohn et al., 2004). Many prenylated flavonoids have been identified as active components in medicinal plants with biological activities, such as anticancer, anti-androgen, anti-leishmania, and anti-nitric oxide production (De Naeyer et al., 2004; Ahmed-Belkacem et al., 2005; Han et al., 2006). Due to the beneficial effects for human health, prenylated flavonoids are of particular interest as lead compounds for producing new drugs and functional foods. "
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