The PedsQLTM Multidimensional Fatigue Scale in pediatric rheumatology: reliability and validity
ABSTRACT OBJECTIVE:. The PedsQL (Pediatric Quality of Life Inventory) is a modular instrument designed to measure health related quality of life (HRQOL) in children and adolescents ages 2-18 years. The recently developed 18-item PedsQL Multidimensional Fatigue Scale was designed to measure fatigue in pediatric patients and comprises the General Fatigue Scale (6 items), Sleep/Rest Fatigue Scale (6 items), and Cognitive Fatigue Scale (6 items). The PedsQL 4.0 Generic Core Scales were developed as the generic core measure to be integrated with the PedsQL Disease-Specific Modules. The PedsQL 3.0 Rheumatology Module was designed to measure pediatric rheumatology-specific HRQOL. Methods. The PedsQL Multidimensional Fatigue Scale, Generic Core Scales, and Rheumatology Module were administered to 163 children and 154 parents (183 families accrued overall) recruited from a pediatric rheumatology clinic. Results. Internal consistency reliability for the PedsQL Multidimensional Fatigue Scale Total Score (a = 0.95 child, 0.95 parent report), General Fatigue Scale (a = 0.93 child, 0.92 parent), Sleep/Rest Fatigue Scale (a = 0.88 child, 0.90 parent), and Cognitive Fatigue Scale (a = 0.93 child, 0.96 parent) were excellent for group and individual comparisons. The validity of the PedsQL Multidimensional Fatigue Scale was confirmed through hypothesized intercorrelations with dimensions of generic and rheumatology-specific HRQOL. The PedsQL Multidimensional Fatigue Scale distinguished between healthy children and children with rheumatic diseases as a group, and was associated with greater disease severity. Children with fibromyalgia manifested greater fatigue than children with other rheumatic diseases. CONCLUSION: The results confirm the initial reliability and validity of the PedsQL Multidimensional Fatigue Scale in pediatric rheumatology.
- SourceAvailable from: Elisa Cainelli
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- "Recently, a Multidimensional Fatigue Scale has been proposed, entailing items from the Pediatric Quality of Life Inventory administered both to children and their parents.44 Goretti et al11 correlated the Pediatric Quality of Life Inventory-Multidimensional Fatigue Scale subjective reports of cognitive and other fatigue-related aspects with occurrence of neuropsychological impairments and psychiatric disorders. "
ABSTRACT: Cognitive and neuropsychological impairments are well documented in adult multiple sclerosis (MS). Research has only recently focused on cognitive disabilities in pediatric cases, highlighting some differences between pediatric and adult cases. Impairments in several functions have been reported in children, particularly in relation to attention, processing speed, visual-motor skills, and language. Language seems to be particularly vulnerable in pediatric MS, unlike in adults in whom it is usually preserved. Deficits in executive functions, which are considered MS-specific in adults, have been inconsistently reported in children. In children, as compared to adults, the relationship between cognitive dysfunctions and the two other main symptoms of MS, fatigue and psychiatric disorders, was poorly explored. Furthermore, data on the correlations of cognitive impairments with clinical and neuroimaging features are scarce in children, and the results are often incongruent; interestingly, involvement of corpus callosum and reduced thalamic volume differentiated patients identified as having a cognitive impairment from those without a cognitive impairment. Further studies about pediatric MS are needed in order to better understand the impact of the disease on brain development and the resulting effect on cognitive functions, particularly with respect to different therapeutic strategies.Neuropsychiatric Disease and Treatment 07/2014; 10:1385-92. DOI:10.2147/NDT.S48495 · 1.74 Impact Factor
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- "Health-related quality of life was assessed using the Pediatric Quality of Life inventory (PedsQL) generic core scales, version 4.0 , while for fatigue, the multidimensional fatigue scale  was employed. The PedsQL generic core scales version 4.0 consists of 23 items which can be completed independently by adolescents. "
ABSTRACT: Benign Joint Hypermobility Syndrome (BJHS) is a major source of morbidity in children and adolescents. Due to fatigue and pain, activities of daily living may be limited. Aim of the work To investigate the relationship between fatigue and health related quality of life in adolescents with BJHS. Patients and methods Thirty adolescents with BJHS and 30 controls were enrolled in the study. All participants were subjected to clinical and laboratory assessment to exclude other causes of fatigue. All were requested to complete self assessment Pediatric Quality of Life (PedsQL) and multidimensional fatigue scale questionnaires. Pain was assessed by Visual Analogue Scale (VAS). Results Compared to healthy adolescents, patients with BJHS had a significant lower total score for PedsQL scale (52.56 ± 8.40 and 87.63 ± 4.68 for patients and controls respectively, p < 0.001) and a significant lower total score for multidimensional fatigue scale (66.09 ± 13.05 and 91.32 ± 3.97 for patients and controls respectively, p < 0.001). General and cognitive fatigue that accompanied BJHS, were the only significant predictors of lower health related quality of life in patients’ group. Among patients with BJHS; general fatigue was a significant predictor for emotional and social function impairment, while cognitive fatigue was a significant predictor for school function reduction. Total multidimensional fatigue scale score, general and cognitive fatigue were predictors of physical function impairment in patients and controls. VAS was highly correlated to PedsQL (r = −0.88, p = <0.001) and multidimensional fatigue (r = −0.99, p = <0.001) scales. Conclusion This study highlights the importance of fatigue as a significant predictor of poor health related quality of life in adolescents with BJHS.Egyptian Rheumatologist 04/2013; 35(2):77–85. DOI:10.1016/j.ejr.2012.12.002
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- "Perceived fatigue will be measured with the Dutch version of the 18-item PedsQL Multidimensional Fatigue Scale . This scale, designed to measure fatigue in pediatric patients, comprises three subscales: the General Fatigue, Sleep/Rest Fatigue and Cognitive Fatigue (Table 3). "
ABSTRACT: Background Burn injuries have a major impact on the patient’s physical and psychological functioning. The consequences can, especially in pediatric burns, persist long after the injury. A decrease in physical fitness seems logical as people survive burn injuries after an often extensive period of decreased activity and an increased demand of proteins leading to catabolism, especially of muscle mass. However, knowledge on the possibly affected levels of physical fitness in children and adolescents after burn injury is limited and pertains only to children with major burns. The current multidimensional study aims to determine the level of physical fitness, the level of physical activity, health-related quality of life and perceived fatigue in children after a burn injury. Furthermore, interrelations between those levels will be explored, as well as associations with burn characteristics. Methods/design Children and adolescents in the age range of 6 up to and including 18 years are invited to participate in this cross-sectional descriptive study if they have been admitted to one of the three Dutch burn centers between 6 months and 5 years ago with a burn injury involving at least 10% of the total body surface area and/or were hospitalized ≥ 6 weeks. Physical fitness assessments will take place in a mobile exercise lab. Quantitative measures of cardiorespiratory endurance, muscular strength, body composition and flexibility will be obtained. Outcomes will be compared with Dutch reference values. Physical activity, health-related quality of life and fatigue will be assessed using accelerometry and age-specific questionnaires. Discussion The findings of the current study will contribute to a better understanding of the long-term consequences of burn injury in children and adolescents after burns. The results can guide rehabilitation to facilitate a timely and optimal physical recovery. Trial registration The study is registered in the National Academic Research and Collaborations Information System of the Netherlands (OND1348800).BMC Pediatrics 12/2012; 12(1):195. DOI:10.1186/1471-2431-12-195 · 1.93 Impact Factor