Article

Portal vein thrombosis during antineoplastic chemotherapy in children: report of five cases and review of the literature.

Imaging Department, Institut Curie, 26 rue d'Ulm, 75005 Paris, France.
European Journal of Cancer (impact factor: 5.54). 01/2005; 40(18):2659-66. DOI:10.1016/j.ejca.2004.06.013 pp.2659-66
Source: PubMed

ABSTRACT We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ultrasonography (US). In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan. In one case, PVT occurred in the absence of HVOD in a patient with pre-existing periportal lymphomatous infiltration. Four patients experienced persistent portal hypertension, which resulted in death in one. PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.

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Keywords

8-year time period
 
Burkitt's lymphoma
 
chemotherapy
 
colour Doppler ultrasonography
 
Ewing's tumour
 
intensive chemotherapy
 
persistent portal hypertension
 
portal vein thrombosis
 
pre-existing periportal lymphomatous infiltration
 
rare event
 
severe hepatic veno-occlusive disease
 
small cell bone tumour
 
thrombosis