Non-specific “non-effects” of vaccination

BMJ (online) (Impact Factor: 17.45). 01/2005; 329(7478):1297-8. DOI: 10.1136/bmj.329.7478.1297
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    • "This effect is likely to be far less pronounced for the first cohort, where considerable efforts were made to bring every child to the vaccination centres, than in the second cohort where standard procedures were used, so that a larger protective effect of vaccines would be expected in the second cohort, if indeed this bias plays a prominent role in the observed association between vaccines and survival, as has been suggested (Fine 2005). Despite these reassuring considerations, many other biases and confounding factors may be present (Fine 2004). For example, pertussis was extensively studied in this area, thus implying that doctors visited every home where a case was reported. "
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    ABSTRACT: Several studies have shown an association between vaccination and child mortality in developing countries. The present paper examines this issue using data from a Senegalese rural area which has been monitored from 1983 to the present. We analysed two birth cohorts, comprising 7796 and 3573 persons who had received either BCG and DTP (diphtheria-tetanus-pertussis) simultaneously or neither of these vaccines, and who had been followed from birth to 2 years of age. The association between vaccinations and mortality was assessed by Cox proportional hazards model. Mortality ratios for recipients of the BCG/DTP combination were 0.59 (95% CI: 0.46-0.74) for the first cohort and 0.70 (0.50-0.97) for the second cohort. Mortality ratios for measles vaccine recipients were 0.98 (0.75-1.27) for the first cohort and 0.87 (0.57-1.30) for the second cohort. The BCG/DTP combination was associated with a reduction in mortality whereas measles vaccination was not associated with mortality.
    Tropical Medicine & International Health 11/2005; 10(10):956-60. DOI:10.1111/j.1365-3156.2005.01479.x · 2.33 Impact Factor
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    BMJ (online) 05/2005; 330(7495):844; author reply 844. DOI:10.1136/bmj.330.7495.844 · 17.45 Impact Factor
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    BMJ (online) 05/2005; 330(7495):845-6. DOI:10.1136/bmj.330.7495.845-a · 17.45 Impact Factor
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