Article

BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.

Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Clinical Infectious Diseases (impact factor: 9.15). 01/2005; 39(12):1861-5. DOI:10.1086/426140 pp.1861-5
Source: PubMed

ABSTRACT Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9-91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7x10(3) vs. 0 copies/mL; P=.008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7x10(3) vs. 0 copies/mL; P=.0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P=.004).

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Keywords

0 copies/mL
 
132 consecutive hematopoietic
 
BK virus DNA
 
Blood samples
 
cell transplant recipients
 
hemorrhagic cystitis
 
patients
 
platelet engraftment
 
postengraftment hemorrhagic cystitis
 
quantitative real-time PCR
 
time-dependent analysis
 
transplantation
 

Veronique Erard