Alcohol consumption and mortality in Serbia: twenty-year follow-up study.
ABSTRACT To investigate the connection between alcohol consumption and general and specific mortality in the Serbian population.
Total of 286 healthy middle-aged participants of both genders enrolled in a prospective follow-up study in 1974. During the following 20 years, 80 deaths occurred. The data on underlying causes of death were obtained from official death certificates. Alcohol consumption was estimated from a multiple-choice questionnaire. According to the total daily alcohol intake, subjects were classified into 3 groups: none- or rare drinkers, moderate, and heavy drinkers. The relative risks (RR) adjusted for gender, smoking, body mass index, and blood pressure were calculated using non-drinkers as a reference category.
Heavy drinkers exhibited significantly higher adjusted ratios for all-cause mortality (RR=1.970, 95% confidence interval [CI]=1.062-3.651; p=0.031) and myocardial infarction (RR=2.463, 95% CI=1.050-5.775; p=0.038), and non-significantly higher risk for death from other causes. Moderate drinkers exhibited lower adjusted risk ratios for all-cause mortality, myocardial infarction and death from other causes, but this decrease did not reach the significance level. Further, overall probability of survival at every time point was the highest among moderate drinkers and lowest among heavy drinkers.
Among Serbian middle-aged population moderate alcohol consumption reduced mortality from all causes, myocardial infarction and other causes of death, and increased the probability of survival in a twenty year follow-up period. Heavy drinking increased mortality rates from all causes and reduced the twenty year-survival probability in comparison with non-drinkers.
Full-textDOI: · Available from: Katarina Paunovic, Jun 12, 2015
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ABSTRACT: To evaluate the joint effect of cigarette smoking and alcohol consumption on mortality. A population-based cohort of 66,743 Chinese men aged 30-89 in Shanghai, China recruited from 1996 to 2000. Lifestyle data were collected using structured questionnaires. As of November 2004, follow-up for the vital status of 64,515 men was completed and death information was further confirmed through record linkage with the Shanghai Vital Statistics Registry. Associations were evaluated by Cox regression analyses. 2514 deaths (982 from cancers, 776 from cardiovascular diseases (CVD)) were identified during 297,396 person-years of follow-up. Compared to never-smokers, both former and current smokers had significantly elevated mortality from any cause, CVD, and cancer; risk increased with amount of smoking. Intake of 1-7 drinks/week was associated with reduced risk of death, particularly CVD death (hazard ratio (HR): 0.7, 95% confidence interval (CI): 0.5, 1.0), whereas intake of >42 drinks/week was related to increased mortality, particularly cancer-related death (HR: 1.7, 95% CI: 1.1, 2.5). The HR for total mortality associated with moderate alcohol consumption increased from 0.8 (95% CI: 0.6, 1.0) for non-smokers to 1.0 (0.9, 1.2) for moderate smokers and 1.4 (95% CI: 1.2, 1.7) for heavy smokers. Heavy drinkers and heavy smokers had the highest mortality (HR: 1.9, 95% CI: 1.6, 2.4). Light and moderate alcohol consumption reduced mortality from CVD. This beneficial effect, however, was offset by cigarette smoking.Preventive Medicine 11/2007; 45(4):313-9. DOI:10.1016/j.ypmed.2007.05.015 · 2.93 Impact Factor
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ABSTRACT: To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes. Systematic review and meta-analysis. A search of Medline (1950 through September 2009) and Embase (1980 through September 2009) supplemented by manual searches of bibliographies and conference proceedings. Inclusion criteria Prospective cohort studies on the association between alcohol consumption and overall mortality from cardiovascular disease, incidence of and mortality from coronary heart disease, and incidence of and mortality from stroke. Studies reviewed Of 4235 studies reviewed for eligibility, quality, and data extraction, 84 were included in the final analysis. The pooled adjusted relative risks for alcohol drinkers relative to non-drinkers in random effects models for the outcomes of interest were 0.75 (95% confidence interval 0.70 to 0.80) for cardiovascular disease mortality (21 studies), 0.71 (0.66 to 0.77) for incident coronary heart disease (29 studies), 0.75 (0.68 to 0.81) for coronary heart disease mortality (31 studies), 0.98 (0.91 to 1.06) for incident stroke (17 studies), and 1.06 (0.91 to 1.23) for stroke mortality (10 studies). Dose-response analysis revealed that the lowest risk of coronary heart disease mortality occurred with 1-2 drinks a day, but for stroke mortality it occurred with ≤1 drink per day. Secondary analysis of mortality from all causes showed lower risk for drinkers compared with non-drinkers (relative risk 0.87 (0.83 to 0.92)). Light to moderate alcohol consumption is associated with a reduced risk of multiple cardiovascular outcomes.BMJ (online) 02/2011; 342(feb22 1):d671. DOI:10.1136/bmj.d671 · 16.38 Impact Factor
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ABSTRACT: This study investigates both general mortality and mortality from myocardial infarction among men employed in iron-ore mines in Sweden. The mortality of employees (surface and underground workers) at the iron-ore mines in Malmberget and Kiruna, Sweden was investigated. The study cohort comprised men who had been employed for at least 1 year between 1923 and 1996. The causes of death were obtained from the national cause of death register from 1952 to 2001. Indirect standardised mortality ratios (SMR) were calculated for four main causes. Mortality specifically from myocardial infarction was also analysed. 4504 deaths in the cohort gave an SMR for total mortality of 1.05 (95% CI 1.02 to 1.09). Mortality was significantly higher for lung cancer (SMR 1.73, 95% CI 1.52 to 1.97). There was an increased risk of injuries and poisonings (SMR 1.34, 95% CI 1.24 to 1.46) and respiratory diseases (SMR 1.14, 95% CI 1.00 to 1.28). There were 1477 cases of myocardial infarction, resulting in an SMR of 1.12 (95% CI 1.07 to 1.18). SMR was higher (1.35, 95% CI 1.22 to 1.50) for men aged <or=60 years than for those >60 years of age (1.06, 95% CI 1.00 to 1.13). Mortality from myocardial infarction was higher than expected. There was also an increased risk of death from injuries and poisonings, lung cancer and respiratory diseases, as well as higher general mortality. Our findings support the results of previous studies that there is an association between working in the mining industry and adverse health outcomes.Occupational and environmental medicine 12/2008; 66(4):264-8. DOI:10.1136/oem.2008.040147 · 3.23 Impact Factor