Alcohol consumption and mortality in Serbia: twenty-year follow-up study.

Institute for Hygiene and Medical Ecology, Belgrade University School of Medicine, Dr Subotica 8, 11000 Belgrade, Serbia and Montenegro.
Croatian Medical Journal (Impact Factor: 1.37). 01/2005; 45(6):764-8.
Source: PubMed

ABSTRACT To investigate the connection between alcohol consumption and general and specific mortality in the Serbian population.
Total of 286 healthy middle-aged participants of both genders enrolled in a prospective follow-up study in 1974. During the following 20 years, 80 deaths occurred. The data on underlying causes of death were obtained from official death certificates. Alcohol consumption was estimated from a multiple-choice questionnaire. According to the total daily alcohol intake, subjects were classified into 3 groups: none- or rare drinkers, moderate, and heavy drinkers. The relative risks (RR) adjusted for gender, smoking, body mass index, and blood pressure were calculated using non-drinkers as a reference category.
Heavy drinkers exhibited significantly higher adjusted ratios for all-cause mortality (RR=1.970, 95% confidence interval [CI]=1.062-3.651; p=0.031) and myocardial infarction (RR=2.463, 95% CI=1.050-5.775; p=0.038), and non-significantly higher risk for death from other causes. Moderate drinkers exhibited lower adjusted risk ratios for all-cause mortality, myocardial infarction and death from other causes, but this decrease did not reach the significance level. Further, overall probability of survival at every time point was the highest among moderate drinkers and lowest among heavy drinkers.
Among Serbian middle-aged population moderate alcohol consumption reduced mortality from all causes, myocardial infarction and other causes of death, and increased the probability of survival in a twenty year follow-up period. Heavy drinking increased mortality rates from all causes and reduced the twenty year-survival probability in comparison with non-drinkers.

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    Central European Journal of Medicine 04/2012; 8(2). · 0.21 Impact Factor
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    ABSTRACT: Aims: To support the Serbian Expert Board in setting up reimbursement for modern pharmacotherapeutic support, we compared a Serbian sample of alcohol-dependent patients with an Austrian sample, in order to detect differences that might inhibit the introduction of anti-craving medications in Serbia. Methods: One hundred and twenty-seven (116 males) alcohol-dependent patients in Serbia and 136 in Austria (78 males) were enrolled consecutively from January 2011 to March 2012 and were assessed using the Lesch alcoholism typology instrument (LAT). Results: Age of onset was slightly higher in the Austrian sample (28.5 vs 30.0; P = 0.10). The Serbian sample showed a higher rate of anxiety disorders than the Austrian sample (89.8 vs 26.5%, P ≤ 0.0001). Suicidal tendencies, independent of alcohol intake or withdrawal syndrome, were higher in the Austrian sample (1.6 vs 13.2% P ≤ 0.0001). There was no difference between the two samples in Lesch-Type IV (26 vs 28); there was a slight excess in the Serbian sample of Type I (15 vs 10). In Austria, significantly more Type II patients (32 vs 52) had been included, while the Serbian sample comprised significantly more Type III patients. Conclusions: Austrian and Serbian patients are quite similar, without any showing any factor that would detract from the potential value of modern anti-craving medications in Serbia. The differences in anxiety disorders might be due to the 1990s war and should be investigated further.
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