Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin

Department of Pathology, 4W35B, New York University School of Medicine, Belluvue Hospital, 462 First Avenue, New York, NY 10016, USA.
Gynecologic Oncology (Impact Factor: 3.77). 02/2005; 96(1):249-53. DOI: 10.1016/j.ygyno.2004.09.040
Source: PubMed


Large cell variant of small cell carcinoma hypercalcemic type (SCC-HT) is extremely rare. All reported cases involved an ovary, and one with primary peritoneal origin has not been described. Also, convincing neuroendocrine granules have not been illustrated.
A 35-year-old woman underwent an exploratory laparotomy for leiomyomas. Intraoperative impression of peritoneal carcinomatosis was confirmed on frozen section. TAH/BSO, debulking/omentectomy followed. The tumor was present on the pelvic/abdominal peritoneum. The normal-sized ovaries were free of tumor grossly. The tumor had features of large cell variant of SCC-HT, described in the ovary. Furthermore, unequivocal neuroendocrine granules were present. The patient received standard chemotherapy for SCC. At 22 months she is NED.
SCC-HT should be considered in the differential diagnosis of primary neoplasms of the peritoneum.

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