Article

Endotoxin recognition and signal transduction by the TLR4/MD2-complex.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, LRB, Room 308, 364 Plantation Street, Worcester, MA 01605, USA.
Microbes and Infection (Impact Factor: 2.73). 01/2005; 6(15):1361-7. DOI: 10.1016/j.micinf.2004.08.015
Source: PubMed

ABSTRACT Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.

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