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Eppig, J. T. et al. The Mouse Genome Database (MGD): from genes to mice—a community resource for mouse biology. Nucleic Acids Res. 33, D471-D475

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Nucleic Acids Research (Impact Factor: 9.11). 02/2005; 33(Database issue):D471-5. DOI: 10.1093/nar/gki113
Source: PubMed

ABSTRACT The Mouse Genome Database (MGD) forms the core of the Mouse Genome Informatics (MGI) system (http://www.informatics.jax.org), a model organism database resource for the laboratory mouse. MGD provides essential integration of experimental knowledge for the mouse system with information annotated from both literature and online sources. MGD curates and presents consensus and experimental data representations of genotype (sequence) through phenotype information, including highly detailed reports about genes and gene products. Primary foci of integration are through representations of relationships among genes, sequences and phenotypes. MGD collaborates with other bioinformatics groups to curate a definitive set of information about the laboratory mouse and to build and implement the data and semantic standards that are essential for comparative genome analysis. Recent improvements in MGD discussed here include the enhancement of phenotype resources, the re-development of the International Mouse Strain Resource, IMSR, the update of mammalian orthology datasets and the electronic publication of classic books in mouse genetics.

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    • "The sAC C1KO mice display male infertility (Esposito et al., 2004). Extensive phenotypic analysis revealed that female mice have increased circulating cholesterol and triglyceride and that both male and female mice have slightly elevated heart rates [as deposited in the Mouse Genome Database (Eppig et al., 2005)]. More recently, it was reported that an alternative start site upstream of exon 5 is used by somatic cells to produce yet another isoforms containing only one catalytic unit C2. "
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    • "Filtering on these three criteria resulted in 548 INDELs that affect 394 human genes (Supplemental Table 5). To gain insight into the likely phenotypic consequences of these disruptions , we identified 101 genes from this set that are associated with targeted disruption phenotypes in the mouse (Supplemental Table 6; Eppig et al. 2005, 2007). Of these 101 experimentally disrupted genes, 84 (83%) yield an abnormal phenotype upon homozygous disruption in the mouse (Supplemental Table 6). "
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    • "A human gene was defined as " essential " if a knockout of its mouse ortholog confers lethality. To find human essential genes, we first extracted mouse essential genes from the Mouse Genome Informatics Database [11], and obtained 2,564 human essential genes through the human-mouse ortholog associations. Using gene symbol mapping we obtained 2,059 essential genes in the UniHI network, and finally used 1,759 of them after removing those that either have been used as drug targets or disease genes, or have some topological features unavailable. "
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