Liver abscess in inflammatory bowel disease: Report of two cases and review of the literature

Department of Internal Medicine A, Hadassah University Hospital, Jerusalem, Israel.
Journal of Gastroenterology and Hepatology (Impact Factor: 3.5). 01/2005; 19(12):1338-42. DOI: 10.1111/j.1440-1746.2004.03368.x
Source: PubMed


Hepatic abscesses are a rare complication of inflammatory bowel disease (IBD). Despite the fact that certain hepatobiliary complications of IBD, including cholelithiasis, primary sclerosing cholangitis (PSC) and cholangiocarcinoma predispose patients with IBD to ascending cholangitis, previously published data does not demonstrate that biliary infection is an important mechanism underlying liver abscess development in these patients. We describe two patients with inflammatory bowel disease, both with PSC, who developed multiple liver abscesses, and review the literature on liver abscesses in association with inflammatory bowel disease.
© 2004 Blackwell Publishing Asia Pty Ltd

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    • "Not surprisingly, periodontal disease and dental procedures are frequently identified as the source of invasive F. nucleatum infection. Similarly, chemotherapy induced oropharyngeal mucositis [21,22] and inflammatory bowel disease [23,24] have been implicated in invasive F. nucleatum infection. "
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    ABSTRACT: Background Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical outcomes. Methods All cases of Fusobacterium spp. bacteremia detected at a regional microbiology laboratory serving outpatient and acute care for a population of approximately 1.3 million people over 11 years were identified from a computerized database. Clinical data on these cases was extracted from an administrative database and analyzed to determine underlying risk factors for and outcomes of infection. Results There were 72 incident cases of Fusobacterium spp. bacteremia over the study period (0.55 cases/100,000 population per annum). F. nucleatum was the most frequent species (61%), followed by F. necrophorum (25%). F. necrophorum bacteremia occurred in a younger population without underlying comorbidities and was not associated with mortality. F. nucleatum bacteremia was found in an older population and was associated with underlying malignancy or receiving dialysis. Death occurred in approximately 10% of F. nucleatum cases but causality was not established in this study. Conclusions Fusobacterium spp. bacteremia in our community is uncommon and occurs in approximately 5.5 cases per million population per annum. F. necrophorum occurred in an otherwise young healthy population and was not associated with any mortality. F. nucleatum was found primarily in older patients with chronic medical conditions and was associated with a mortality of approximately 10%. Bacteremias from other Fusobacterium spp. were rare.
    BMC Infectious Diseases 06/2013; 13(1):264. DOI:10.1186/1471-2334-13-264 · 2.61 Impact Factor
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    • "Liver abscesses are a rare complication of IBD, and most cases have been described in patients with Crohn's disease. However, they have also rarely been reported in association with ulcerative colitis, with only seven cases reported in the literature (3-9). Why liver abscesses are less frequent in patients with ulcerative colitis than in Crohn's disease is poorly understood (10). "
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    ABSTRACT: Liver abscesses are very rare complications of ulcerative colitis, and furthermore, there has been only one case of splenic abscess in a patient with ulcerative colitis reported in the English literature. We recently encountered a patient with ulcerative colitis accompanied by both hepatic and splenic abscesses. The patient was treated with abscess drainage as well as sulfasalazine and antibiotics. Follow-up sonography of the abdomen showed complete resolution of the lesions. To our knowledge, this is the first report of combined case of multiple liver abscesses combined with splenic abscess in a patient with ulcerative colitis.
    Journal of Korean Medical Science 09/2007; 22(4):750-3. DOI:10.3346/jkms.2007.22.4.750 · 1.27 Impact Factor
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    ABSTRACT: Hepatobiliary Diseases (HBDs) accompanies in a 5-10% of patients with Inflammatory Bowel Diseases (IBD). They are either extra-intestinal manifestations or drug side effects. The main extra-intestinal manifestation is Primary Scle-rosing Cholangitis (PSC), which as an entity, includes the former “pericholangitis”, now called small duct Primary Sclerosing Cholangitis. It mainly affects young males with ulcerative colitis. It is a chronic cholestatic disease with a broad spectrum of clinical manifestations. The asympto-matic disease has a better prognosis than the symptomatic one. It eventually leads to cirrhosis and is the 4 th cause of orthotopic liver transplantation. Cholangiocarcinoma is the most ominous complication and its presence is also accom-panied by increased frequency of colon dysplasia or can-cer. A less frequent complication is the ascending cholan-gitis with or without (pigmented) biliary stones. Auto-immune Hepatitis (type-1) is another extra-intesti-nal manifestation of IBD, but its frequency seems to be very low under the new diagnostic criteria, compared to the fre-quency reported in previous publications. An overlap syn-drome may also occur.
    Annals of Gastroenterology 01/2006; 19(2).
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