Methionine production by fermentation.

Department of Biotechnology, Sun Pharma Advanced Research Centre, Vadodara-390 020, India.
Biotechnology Advances (Impact Factor: 9.6). 02/2005; 23(1):41-61. DOI: 10.1016/j.biotechadv.2004.08.005
Source: PubMed

ABSTRACT Fermentation processes have been developed for producing most of the essential amino acids. Methionine is one exception. Although microbial production of methionine has been attempted, no commercial bioproduction exists. Here, we discuss the prospects of producing methionine by fermentation. A detailed account is given of methionine biosynthesis and its regulation in some potential producer microorganisms. Problems associated with isolation of methionine overproducing strains are discussed. Approaches to selecting microorganism having relaxed and complex regulatory control mechanisms for methionine biosynthesis are examined. The importance of fermentation media composition and culture conditions for methionine production is assessed and methods for recovering methionine from fermentation broth are considered.

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