A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: Diagnosis, management, and outcome

Department of Paediatrics, Juntendo University, Edo, Tōkyō, Japan
Journal of Pediatric Surgery (Impact Factor: 1.39). 01/2005; 39(12):1782-3. DOI: 10.1016/j.jpedsurg.2004.08.030
Source: PubMed


A neonate with stage IV bilateral adrenal neuroblastoma associated with metastases to the skin, liver, bone marrow, and right ocular conjunctiva is reported. At birth, skin metastases were present all over the body. He underwent a combination of chemotherapy, surgery, and peripheral blood stem cell transplantation (PBSCT). Histopathology was unfavorable with diploid tumor cell DNA content and low levels of TRK-A mRNA expression. Skin and conjunctival metastases disappeared after PBSCT, and there have been no signs of recurrence after 5 years of follow-up. Accurate staging of disease and histologic examination followed by intensive management are essential even in infants with neuroblastoma to ensure successful outcome.

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