Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter
ABSTRACT Tandem repeat number polymorphism of a CCTTT pentanucleotide in the promoter region of the inducible nitric oxide synthase gene (iNOS) and a polymorphism of the interleukin-1beta (IL-1B) promoter at position -31 were analyzed in DNA samples from 181 Japanese control subjects and 158 gastric cancer patients, including 96 intestinal type and 62 diffuse type. An association between the intestinal type of gastric adenocarcinoma and higher promoter activity of the iNOS gene was found in women, especially those having higher promoter activity of the IL-1B gene and without a history of smoking. Our results imply that chronic inflammation caused by excess nitric oxide generated by iNOS contributes to Helicobacter pylori-induced gastric cancer.
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- "Later studies have however indicated a contribution for this polymorphism in some other cancers including gastric and urothelial carcinomas, where the high activity 'longer' alleles (n > 11) generally enhance disease susceptibility or progression(Kaise et al. 2007; Sawa et al. 2008; Shen et al. 2007; Tatemichi et al. 2005). "
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ABSTRACT: Research into technology for removal of CO2 considered to be the major cause of global warming, was applied to electric power plant flue gas. Our method was to use zeolite as adsorbent for physical adsorption, progressing from the previously used PSA (Pressure Swing Adsorption) method to the more advanced PTSA (Pressure and Temperature Swing Adsorption) method. We have been conducting basic research since the 1980s, and in 1991 built a 1000m3N/h scale pilot plant, where we are continuing research through trial operation. Trial operation of the pilot plant has been mainly for acquisition of scale up data, as well as improvement in the decrease in the power consumption of PTSA units. As a result, we have seen a better than 20% improvement in that area. In addition, the pilot plant completed 2000 hours of continuous operation without incident between October and December, 1994. The total hours of operation of the plant have topped 4000 hours, but we have seen no decrease in the effectiveness of the CO2 adsorbent. The SOx in the flue gas was trapped in the lower part of desiccant in PSA-H2O before the process. Some of desiccant reacts to that, but we have prevented any ill effects on the process that might be caused by main units. At this point we would like to report on the results of our research, as well as outline our plants for the future.Energy Conversion and Management 06/1996; DOI:10.1016/0196-8904(95)00279-0 · 3.59 Impact Factor
- Value in Health 11/2004; 7(6):805-805. DOI:10.1016/S1098-3015(10)66162-1 · 2.89 Impact Factor