Vision-related quality of life in patients with bilateral severe age related macular degeneration

Duke University, Durham, North Carolina, United States
Ophthalmology (Impact Factor: 6.17). 02/2005; 112(1):152-8. DOI: 10.1016/j.ophtha.2004.06.036
Source: PubMed

ABSTRACT To determine the quality of life (QOL) of patients with bilateral severe age-related macular degeneration (AMD) before macular translocation with 360 degrees peripheral retinectomy.
Prospective, consecutive, noncomparative case series.
An observational study assessed vision-related and general health QOL using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) and the Medical Outcomes Study 12-item short form (SF-12) surveys, respectively. Mean QOL scores were correlated with patient age, duration of vision loss, and visual function. Mean QOL scores in study patients were compared with mean QOL scores in groups of patients with low vision, patients with AMD of varying severity, and reference populations.
National Eye Institute VFQ-25 and SF-12 QOL scores.
Seventy patients with a mean age of 76.4 years were studied. Mean distance visual acuity (VA) was 62.4 (Early Treatment Diabetic Retinopathy Study letters), mean near VA was 0.81 (logarithm of the minimum angle of resolution), and mean reading speed was 74.9 words per minute. Important NEI VFQ-25 quality of vision subscales (general vision, difficulty with distance tasks, difficulty with near tasks) and vision-specific subscales (dependency, role difficulties, mental health, social function limitations) tended to correlate negatively with increasing patient age and duration of vision loss, but correlated positively with better VA and reading speed. The mean QOL scores for these important quality of vision and vision-specific subscales were significantly worse than or similar to mean scores in patients with low vision, and significantly worse than scores in patients with AMD of varying severity and a reference population. The mean SF-12 physical composite score in study patients was similar to that seen in patients with AMD of varying severity, but significantly higher than that in patients with low vision and a reference population. The SF-12 mental composite score in study patients was similar to those of all 3 comparison groups.
Patients with bilateral severe AMD have vision-related QOL similar to that of patients with low vision but significantly worse than those of patients with AMD of varying severity and persons without eye disease. This inability to perform vision-related daily tasks is not related to general health problems.

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    • "Central, high acuity vision is often compromised in patients with AMD, with peripheral vision typically being preserved. The loss of central vision associated with AMD profoundly impacts upon the ability to perform activities such as reading, writing, driving and recognising faces (Berdeaux, Nordmann, Colin, & Arnould, 2005; Cahill et al., 2005). Vision loss such as this can preclude healthy and independent ageing, and contribute to a reduction in quality of life (Hassell et al., 2006; Mitchell & Bradley, 2006). "
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    ABSTRACT: Current therapy to slow disease progression in patients with neovascular age-related macular degeneration (AMD) often entails intra-vitreal injection of an anti-vascular endothelial growth factor (VEGF) agent, that begins with a three-month loading phase of four weekly injections followed by regular monthly visits with clinician-determined re-treatment. The effects of AMD on quality of life and visual function have been extensively reported in the literature, however, less is known about the burden imposed on patients by the arduous and often indefinite treatment schedule which habitually follows a diagnosis of wet AMD. To date, no systematic review has been conducted of research investigating patients' experiences of anti-VEGF treatment for AMD. A systematic search of the Embase, Medline, PsycINFO and PubMed electronic databases was undertaken to identify all studies between January 2004 and December 2013, published in the English language and involving human participants. A hand-search of an additional four journals was conducted. Ten articles were identified for inclusion in this review. A critical appraisal was undertaken using the Critical Appraisal Skills Programme Qualitative Research Checklist and the results synthesised to form a narrative review. Few studies to date have investigated patients' experiences of treatment for AMD. These studies have focused primarily on patients' experiences of the injection procedure with respect to pain and anxiety. Anticipated discomfort is often greater than actual discomfort experienced during intra-vitreal injection. However, different stages of the treatment procedure produce varying levels of patient discomfort. No one method of anaesthesia has consistently been shown to be more effective in reducing discomfort associated with treatment. Common reasons underlying patient apprehension surrounding treatment include the thought of having an injection, fear of losing eyesight and fear of the unknown. Whilst these studies have not been without their methodological limitations, they provide a platform for further exploration of the patient experience.
    Psychology Health and Medicine 08/2014; In Print(3). DOI:10.1080/13548506.2014.936886 · 1.53 Impact Factor
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    • "The most severe vision loss occurs in the neovascular form of AMD (nvAMD), involving choroidal neovascularization associated with retinal edema [2]. Even when AMD does not lead to blindness, there is a strong negative impact on independence and quality of life [3]. Worldwide, 25 million "
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    Journal of Ophthalmology 02/2014; 2014:346360. DOI:10.1155/2014/346360 · 1.94 Impact Factor
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    • "The prevalence of AMD will rise due to increasing life expectancy and the demographic shift towards an elderly population [6] [7]. VC AMD has a significant adverse impact on daily living, independence, emotional well being and overall quality of life, which are related to disease severity [8] [9] [10], not to mention the substantial personal and societal burden that this condition represents [11] [12]. The aetiology of AMD is poorly understood, yet there is consensus that genetic background and certain environmental/lifestyle risk factors, and their interaction, "
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