Variation of the polymorphic region X of the protein A gene during persistent airway infection of cystic fibrosis patients reflects two independent mechanisms of genetic change in Staphylococcus aureus.

Barbara C Kahl, Alexander Mellmann, Susanne Deiwick, Georg Peters, Dag Harmsen

Institute of Medical Microbiology, University of Muenster, Domagkstr. 10, 48149 Muenster, Germany.

Journal Article: Journal of Clinical Microbiology (impact factor: 4.16). 02/2005; 43(1):502-5. DOI: 10.1128/JCM.43.1.502-505.2005

Abstract

Variation of the polymorphic region of the protein A gene (spa) was observed during long-term persistence of Staphylococcus aureus in the airways of 10 cystic fibrosis patients and occurred at a rate of one genetic change every 70 months. Independent mutational events were observed eight times in 142 isolates: four deletions, two duplications of repeats, and two point mutations.

Source: PubMed

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Keywords

10 cystic fibrosis patients
 
70 months
 
airways
 
genetic change
 
point mutations
 
polymorphic region
 
Staphylococcus aureus