Melissa officinalis L. (Lamiaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the volatile oil components of M. officinalis on Herpes simplex virus type 2 (HSV-2) replication in HEp-2 cells. Four different concentrations (25, 50, 100, 150 and 200 microg/ml) of volatile oils were examined. Experiments were carried out using HEp-2 cells. M. officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 micro/ml. It was, however, found to be slightly toxic at a concentration over of 100 microg/ml. The antiviral activity of non-toxic concentrations against HSV-2 was tested. The replication of HSV-2 was inhibited, indicating that the M. officinalis L. extract contains an anti-HSV-2 substance.
"Conversely, Allahverdiyev et al. (2004) showed that the most prevalent compounds are β–Cubebene, β– Caryophyllene (the only common compound between the studies), Sesquiterpene alcohol (C15H26O), α -Cadinol, Geranial (citral a), and Neral (citral b) (Table 1). The different results in these two previous studies could come from the use of different extraction and identification methods; Allahverdiyev et al. (2004) used mass spectrophotometry ensuring greater reliability on the results because of the high sensitivity of this method compared to those using older identification methods. However, compounds other than those cited in the present article, such as rosmarinic acid (Boyadzhiev and Dimitrova, 2007), have been found indicating that a wide range of compounds in this plant could hinder the identification of all compounds in its composition. "
[Show abstract][Hide abstract] ABSTRACT: The anxiety disorders prevalence has significantly increased in society. These disorders can be treated with anxiolytics which, despite great efficacy, may result in several adverse side effects. Several studies have reported that anxiolytic effects result from the indirect action on the GABAergic system and mechanisms related to the cholinergic system. Melissa officinalis has been widely utilized for its sedative action and its ability to reduce agitation. Several studies using this plant in different experimental models have demonstrated its low toxicity and lack of side effects. Therefore, this study presents a literature review of the active principles responsible for the anxiolytic effect of M. officinalis and the mechanisms involved in this effect.
African journal of pharmacy and pharmacology 01/2015; 9(3):53. DOI:10.5897/AJPP2014.4180 · 0.84 Impact Factor
"Three types of plants were selected to facilitate a sensitivity analysis of testing for lack of activity as an indication of virus viability: (1) a plant with no known antiviral activity (Cucumis sativus peel); (2) a plant known to be generally toxic (Nerium oleander ) (Turan et al., 2006)); and (3) plants that have been reported as antiviral agents (F. benjamina, Mentha longifiolia, O. syriacum, M. officinalis (Allahverdiyev et al., 2004; Geuenich et al., 2008; Vimalanathan and Hudson, 2012; Yarmolinsky et al., 2010). "
[Show abstract][Hide abstract] ABSTRACT: Viruses cause a variety of illnesses in humans, yet only a few antiviral drugs have been developed; thus, new antiviral drugs are urgently needed. Plants could be a good source of antiviral drugs, they do not have mobility and can only defend themselves by producing compounds against pathogens such as viruses in their own fix environment. These compounds may have the potential to inhibit animal and human viruses as well. In this study, a fast and reliable method for screening plant extracts for specific antiviral activity against Herpes simplex virus type-1 (HSV-1) was developed. This method distinguishes between host cell death due to infectivity and multiplicity of the virus versus toxicity of the plant extract. Extracts from 80 plant and plant organs were screened using this approach. Six plant extracts showed potential to exert specific HSV-1 growth inhibition activity. In two cases, different organs from the same plant showed similar active results. With this method it is possible to screen a large number of extracts in a rapid and accurate way to detect antiviral substances against HSV-I and other viruses.
"Lemon balm is used for several purposes such as an additive in food, a herb tea, an ingredient in cosmetics, an ornamental and a medicine. Essential oil is currently used in medicine and pharmacology (anti-tumor, anti-bacterial, antimicrobial, antihistaminic, antispasmodic and antioxidant, by means of its antiviral effect curing of the herpes, antiulcerogenic, moderate Alzheimer's disease, modulation of mood and cognitive performance, stimulating the immune system (against anti HIV-1)  . There are several commercially available chemical compounds that could be used as elicitors to modify plant secondary metabolites and subsequently the bioactivity of medicinal plants. "
[Show abstract][Hide abstract] ABSTRACT: Lemon balm (Melissa officinalis L.), member of Lamiaceae family, is one of the important medicinal plant species. In this study we were investigated the effects of Salicylic hydroxamic acid(SHAM) on seed germination and yield of lemon balm. It was conducted at Agriculture Research Center of Hamedan Province in 2013. SHAM used in 4 different concentrations (0, 50, 75, 100 ppm). Seeds were primed for 8 hours in each concentration, and planted in petri dish. Then, we were assessment some parameter such as seed germination, germination speed, root length, root weight, shoot length, shoot weight, seedling dry weight, enzyme activity, catalase, and peroxidase. This study indicated that SHAM had significant effects on all germination traits and biochemical parameters. Comparison of mean effects of SHAM revealed that the highest germination percent (89%), germination speed (5.41), shoot length (21.15 mm), root length (17 mm), fresh weight (38 mg) and dry weight (8.12 mg). The highest catalase enzymes (23 micromole/mg) and highest peroxidase action (25.66 micromole/mg) were observed at the control concentration. It can be concluded that the SHAM has antioxidant properties and regulate resporiratory system.
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