Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2. Phytomedicine 11(7-8):657-661

Tropical Diseases Center, Faculty of Medicine, Cukurova University, Adana, Turkey.
Phytomedicine (Impact Factor: 3.13). 12/2004; 11(7-8):657-61. DOI: 10.1016/j.phymed.2003.07.014
Source: PubMed


Melissa officinalis L. (Lamiaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the volatile oil components of M. officinalis on Herpes simplex virus type 2 (HSV-2) replication in HEp-2 cells. Four different concentrations (25, 50, 100, 150 and 200 microg/ml) of volatile oils were examined. Experiments were carried out using HEp-2 cells. M. officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 micro/ml. It was, however, found to be slightly toxic at a concentration over of 100 microg/ml. The antiviral activity of non-toxic concentrations against HSV-2 was tested. The replication of HSV-2 was inhibited, indicating that the M. officinalis L. extract contains an anti-HSV-2 substance.

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    • "Conversely, Allahverdiyev et al. (2004) showed that the most prevalent compounds are β–Cubebene, β– Caryophyllene (the only common compound between the studies), Sesquiterpene alcohol (C15H26O), α -Cadinol, Geranial (citral a), and Neral (citral b) (Table 1). The different results in these two previous studies could come from the use of different extraction and identification methods; Allahverdiyev et al. (2004) used mass spectrophotometry ensuring greater reliability on the results because of the high sensitivity of this method compared to those using older identification methods. However, compounds other than those cited in the present article, such as rosmarinic acid (Boyadzhiev and Dimitrova, 2007), have been found indicating that a wide range of compounds in this plant could hinder the identification of all compounds in its composition. "
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