Article

Search for a novel biomarker for the brain cancer astrocytoma by using surface enhanced laser desorption/ionisation (SELDI) technique.

Biological Sciences Department, Elizabeth City State University under The University of North Carolina, Elizabeth City, NC 27909, USA.
Cellular and molecular biology (impact factor: 0.98). 10/2004; 50(6):733-6. pp.733-6
Source: PubMed

ABSTRACT The protein chip surface enhanced laser desorption/ionisation (SELDI) technique is a highly versatile analytical mass spectrometry system with considerable potential for detection, identification and quantitation of protein complex mixtures. Astrocytoma is a tumour of the astrocytes with a very poor prognosis. There is no effective biomarker system for detection of astrocytoma. The SELDI technique was used to study differential protein expression in astrocytoma cells in comparison to normal brain astrocytes. Several novel proteins were found to be expressed in the astrocytoma cells, not present in the astrocytes.

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Keywords

astrocytes
 
considerable potential
 
effective biomarker system
 
laser desorption/ionisation
 
normal brain astrocytes
 
poor prognosis
 
protein chip surface
 
protein complex mixtures
 
SELDI
 
SELDI technique
 
study differential protein expression
 
versatile analytical mass spectrometry system