Article

Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis.

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, 1-754 Asahimachi-dori, Niigata City 951-8510, Japan.
European Journal of Heart Failure (impact factor: 4.9). 01/2005; 7(1):109-12. DOI:10.1016/j.ejheart.2004.03.006 pp.109-12
Source: PubMed

ABSTRACT The disease course of acute myocarditis has a wide spectrum and the predictors of the prognosis in patients with acute myocarditis have not yet been established. In the pathogenesis of myocarditis, the cytokine environment is important. In this study, we examined the predictive values of serum levels of interleukin-10 (IL-10) and IL-12 in the short-term prognosis of patients with acute myocarditis. Twenty-four consecutive patients who had been diagnosed as having acute active myocarditis were analyzed and monitored for 2 months. The patients with myocarditis were divided into the survival group (n=16) and the non-survival group (n=8). Initial serum levels of IL-10 (P=0.0015) and IL-12 (P=0.012) in the non-survival group were significantly higher than those of the survival group, and there was a significant correlation between IL-10 and IL-12 levels (P<0.0001). The univariate analyses showed that increased serum levels of IL-10 (hazard ratio 1.041, P=0.0004) and IL-12 (hazard ratio 1.128, P=0.0346) were significant predictors of mortality. In the Kaplan-Meier analysis, high levels of IL-10 (>or=7.0 pg/ml) (P=0.0239) strongly predicted high mortality. In conclusion, the elevation in serum IL-10 levels at the initial phase appeared to predict poor short-term prognosis in patients with acute myocarditis.

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Keywords

2 months
 
acute active myocarditis
 
acute myocarditis
 
cytokine environment
 
disease course
 
IL-12 levels
 
increased serum levels
 
initial phase
 
Initial serum levels
 
non-survival group
 
poor short-term prognosis
 
predictive values
 
predictors
 
serum IL-10 levels
 
serum levels
 
short-term prognosis
 
significant correlation
 
survival group
 
univariate analyses
 
wide spectrum