Virus-associated trichodysplasia spinulosa (VATS) is a cutaneous eruption of spiny papules predominantly affecting the face that is associated with a distinctive histologic picture of abnormally maturing anagen follicles with excessive inner root sheath differentiation and hyperkeratotic infundibula. Ultrastructurally, intranuclear viral particles consistent with polyoma virus are found. Only 2 patients have thus far been reported. Both had developed the eruption after a kidney transplant. We report 2 additional cases of VATS. One is an 8-year-old boy who presented with facial papules after a kidney transplant. The other is a 19-year-old man with a history of acute lymphocytic leukemia who never had a transplant. He developed a papular facial eruption as well as alopecia. Light microscopic and ultrastructural examinations revealed a spectrum in the severity of the histologic alterations as well as the number of intranuclear viral particles. This report expands the range of pathologic alterations associated with VATS and documents for the first time that it can affect patients without a solid organ transplant. The similarity of the clinical and histologic features of VATS with those previously reported by others as cyclosporine-induced "follicular dystrophy" or "pilomatrix dysplasia" raises the possibility that the described phenomena may reflect the same entity. Increased awareness of the distinct histologic picture associated with VATS will likely lead to more frequent diagnosis of this underrecognized entity.
"Electron microscopy of skin showed presence of intracellular viral particles. This entity has lately been reported in immunosuppressive states in patients without organ transplantation such as leukemias and lymphoma.[133–136] van der Meijden et al. described the discovery of a new polyoma virus in a patient with trichodysplasia spinulosa. "
[Show abstract][Hide abstract] ABSTRACT: Madarosis is a terminology that refers to loss of eyebrows or eyelashes. This clinical sign occurs in various diseases ranging from local dermatological disorders to complex systemic diseases. Madarosis can be scarring or non-scarring depending upon the etiology. Appropriate diagnosis is essential for management. Follicular unit transplantation has been found to be a useful method of treating scarring madarosis and the procedure relevant to eyebrow and eyelash reconstruction has been discussed. A useful clinical approach to madarosis has also been included for bedside diagnosis. The literature search was conducted with Pubmed, Medline, and Google scholar using the keywords madarosis, eyebrow loss, and eyelash loss for articles from 1960 to September 2011. Relevant material was also searched in textbooks and used wherever appropriate.
International Journal of Trichology 03/2012; 4(1):3-18. DOI:10.4103/0974-7753.96079
"Trichodysplasia spinulosa (TS) is a rare disease of the skin seen in solid organ transplant patients receiving immunosuppressive therapy (1–5) and in lymphocytic leukemia patients (4,6–8). A total of 15 TS cases have been described, of which 3 were identified in 2010 (9–11). "
[Show abstract][Hide abstract] ABSTRACT: We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa-associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromised patients. To investigate this hypothesis, we developed and used a Luminex-based TSV viral protein 1 immunoassay, excluded cross-reactivity with phylogenetically related Merkel cell polyomavirus, and measured TSV seroreactivity. Highest reactivity was found in a TS patient. In 528 healthy persons in the Netherlands, a wide range of seroreactivities was measured and resulted in an overall TSV seroprevalence of 70% (range 10% in small children to 80% in adults). In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age.
[Show abstract][Hide abstract] ABSTRACT: , Department of Applied Mathematics, Tongji University, Shanghai, China Taught: Complex Analysis, Differential Geometry, and Calculus 1985--1988 Assistant, Department of Applied Mathematics, Tongji University, Shanghai, China Taught: Linear Algebra, Analytic Geometry, and Calculus Affiliations SIAM IEEE & IEEE Computer Society American Mathematical Society Mathematical Association of America Honors 1992--1993 Graduate Fellowship, Center for Applied Mathematics, University of Notre Dame 1989--1990 Graduate Fellowship, Department of Mathematics, University of Notre Dame Selected Publications 1. "Spectra and Pseudospectra of Block Toeplitz Matrices", with A. Lumsdaine, Linear Algebra and its Applications, 1997, accepted. 2. "Spectra and Pseudospectra of the Waveform Relaxation Operators", with A. Lumsdaine, SIAM Journal on Scientific Computing, Vol. 18, No. 1, January 1997. 3. "On the Integral R
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