Article

Quality-of-life measurement in patients undergoing radiation therapy for head and neck cancer: a Hong Kong experience.

Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
The Journal of oncology management: the official journal of the American College of Oncology Administrators 13(6):13-23.
Source: PubMed

ABSTRACT The aims of this study are (1) to establish a reliable and valid quality-of-life (QOL) questionnaire for Chinese patients with head and neck (H&N) cancer who are treated with radiation therapy and (2) to evaluate the impact of the immediate side effects of treatment on the QOL of these patients. The 39-item "Quality of Life Radiation Therapy Instrument with Head and Neck Companion Module" (QOL-RTI/H&N) was translated into Chinese. In the reliability evaluation phase (study module 1), the questionnaire was administered twice to 56 H&N cancer patients, 7 days apart, during the second and third week of radiation therapy. In the validity evaluation phase (study module 2), 138 patients completed the QOL-RTI/H&N before starting and at the end of radiation therapy. Sixty-nine of these 138 patients also completed the QOL-RTI/H&N during the second week of their radiation therapy, at the same time as completing the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) questionnaire. Cronbach alpha coefficients were 0.88 for the general-tool QOL-RTI and 0.90 for the H&N subscale. Test-retest reliability was satisfactory with intraclass correlation coefficients of 0.89 for the general-tool QOL-RTI and 0.75 for the H&N subscale. The instrument can discriminate between patients with stage I or II disease and those with stage III or IV disease (P < .05). Concurrent validity was established by the good agreement with the FACT-H&N (r = 0.86, P < .001). A highly significant deterioration was in the QOL from the baseline to the end of treatment (mean difference for general tool = 1.95, P < .001; mean difference for H&N subscale = 4.85, P < .001). The Chinese QOL-RTI/H&N is a reliable and valid tool for determining the QOL in H&N cancer patients receiving radiation therapy. The immediate side effects of treatment had a significantly negative impact on the patients' QOL. The impact was relatively large for the functional and treatment-site aspects.

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31 May 2013

Keywords

56 H&N cancer patients
 
Cancer Therapy-Head
 
Chinese patients
 
Chinese QOL-RTI/H&N
 
Functional Assessment
 
general tool
 
H&N cancer patients
 
Life Radiation Therapy Instrument
 
Neck Companion Module
 
negative impact
 
patients' QOL
 
reliability evaluation phase
 
second week
 
study module 1
 
study module 2
 
Test-retest reliability
 
third week
 
treatment-site aspects
 
valid tool
 
validity evaluation phase