Body fluid distribution in elderly subjects with congestive heart failure.

Department of Medical and Surgical Sciences, Division of Geriatrics, University of Padua, Padua, Italy.
Annals of clinical and laboratory science (Impact Factor: 0.84). 02/2004; 34(4):416-22.
Source: PubMed

ABSTRACT The aims of this study were to investigate body fluid changes in elderly patients suffering from congestive heart failure (CHF) and to identify the fluid measurement that best characterizes fluid overload states in CHF patients by comparison with normal hydration in the elderly. In a case-controlled experimental design, 72 elderly subjects (65-98 yr), 38 healthy and 34 with CHF, were studied. Total body water (TBW) and extracellular water (ECW) were determined by dilution methods; fat-free mass (FFM) and fat mass (FM) were determined by dual-energy X-ray absorptiometry (DEXA). In healthy subjects, the FFM hydration expressed as TBW% FFM (males 72.0 +/- 4.3 vs females 72.4 +/- 5.0%) and ECW% TBW (males 47.3 +/- 3.4 vs females 47.8 +/- 5.1) were similar in both genders. ECW in liters for FFM and for TBW (ECW% TBW), corrected for body weight, was greater in the group with CHF than in the control group, in both sexes. Among the relative fluid measures, only ECW% TBW [odds ratio (OR) 1.5] independently predicted fluid retention. Having an ECW% TBW greater than 50% corresponded to an OR of about 10. In conclusion, elderly patients suffering from CHF have a characteristic increase in body fluid levels, mainly affecting the extracellular compartment, and ECW% TBW is a useful indicator of fluid retention.


Available from: Luca Busetto, Jun 15, 2015
  • [Show abstract] [Hide abstract]
    ABSTRACT: Heart Failure (HF) is a complex syndrome, which can include the physiological, neural hormonal and metabolic complications known as "Cardiac Cachexia" (CC). In the development of CC there is a release of catabolic cytokines (Tumor Necrosis Factor-α, interleukins 1 and 6) that cause a decrease of fat free mass and fat mass. These changes in body composition might be reversed with a therapeutic combination of resistance exercise and branched chain amino acid supplementation (BCAA). Evaluate changes in body composition after a resistance exercise program and BCAA supplementation in patients with HF. In a randomized clinical trial with 3 month of follow-up anthropometric body composition analysis and stress tests were evaluated at the beginning and in the end of the study. Patients were divided into two groups; the experimental group performed the resistance exercise program and received 10 g/day BCAA supplementation, and the control group only performed the resistance exercise program. Both groups were provided with individualized diets and conventional medical treatment. Changes were found in hip circumference between the groups (p = 0.02), and muscle strength was increased in the experimental group (8%) and the control group (11.4%) with no difference between them. METS and VO2Max also increased in experimental and control groups (16.6% and 50.1% respectively). Regarding changes in symptoms, improvements in fatigue (45.4%), decubitus intolerance (21.8%) and dyspnea (25.4%) were observed in the overall sample. Improvements in physical and functional capacities are attributed to resistance exercise program but not to the BCAA supplementation. Clinical Trials Identifier: NCT02240511. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
    Clinical nutrition (Edinburgh, Scotland) 02/2015; DOI:10.1016/j.clnu.2015.02.004 · 3.94 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In view of the environmental, food-safety and health related issues associated with the application of chemical insecticides, growing emphasis is being laid on insect-pest control through plant resources. Mentha (mint) is one of the most common herb which has been known for its medicinal and aromotherapeutic properties since ancient times and in the last few decades, its insecticidal potential has also been investigated. The present review consolidates studies concerning insecticidal activity of Mentha against various stored grain pests and vectors. Insecticidal properties of different Mentha species are commonly inherent in its essential oils or plant extracts which is correlated with their chemical composition. Insect/pest control potential of various Mentha species has been evaluated by conducting adulticidal, larvicidal and growth/reproduction inhibition bioassays. Fumigant and repellent activity of Mentha essential oil has been studied against several stored grain pests (Tribolium castaneum, Sitophilus oryzae, Acanthoscelides obtectus, etc.) and vectors. Nevertheless, studies exploring larvicidal and growth/reproduction regulatory activity of Mentha, are relatively less. Among the vectors, mosquitocidal activity of several Mentha essential oils and their constituents is established. However, the studies directed towards formulation or product development and performance assessment in actual field conditions are lacking. Hence, although a ground has been set based on the lab scale research investigations, field studies on these aspects are warranted to ensure wide scale application.
    Industrial Crops and Products 07/2011; 34(1):802-817. DOI:10.1016/j.indcrop.2011.02.019 · 3.21 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the reliability of bioelectrical impedance analysis (BIA) in estimating total body water (TBW) and extracellular water (ECW) in elderly patients suffering from congestive heart failure (CHF). In 72 elderly subjects, 34 with CHF (aged 83.9+/-6.9 years) and 38 healthy controls (78.7+/-7.5 years), TBW and ECW values were assessed using dilution methods, and bioelectrical variables were measured using single frequency BIA (SF-BIA) at 1 and 50 kHz, and bioelectrical spectroscopy (BIS). In CHF patients, Ht(2)/R(1) correlated weakly with TBW (r = 0.56) and ECW (0.47). In both healthy controls and CHF patients, TBW correlated strongly with Ht(2)/R(50), Ht(2)/R(0), Ht(2)/R(8) and Ht(2)/Zc. Using multiple regression analysis and the Bland-Altmann approach, SF-BIA at 50 kHz and BIS proved similar in predicting TBW for both the explained variance (R(2)~0.89) and the limits of agreement. In all subjects, ECW was estimated best by including height, weight and Ht(2)/R(0 )(R(2) 0.75) or Ht(2)/Zc (R(2) 0.77) in multivariate models, while SF-BIA at 50 kHz did not explain more than 71 % of ECW variability. The SEE % was nonetheless about twice the SEE % for estimating TBW. SF-BIA at 1 kHz is unreliable in predicting body fluids in elderly people with CHF. SF-BIA at 50 kHz and BIS are useful for estimating TBW in healthy elderly people and in cases of water imbalance, but both methods are less reliable in estimating ECW, particularly in conditions of fluid overload.
    Scandinavian Journal of Clinical and Laboratory Investigation 02/2006; 66(1):19-30. DOI:10.1080/00365510500402158 · 2.01 Impact Factor