Antioxidant betalains from cactus pear (Opunda ficus-indica) inhibit endothelial ICAM-1 expression

Università degli Studi di Palermo, Palermo, Sicily, Italy
Annals of the New York Academy of Sciences (Impact Factor: 4.31). 01/2005; 1028:481-6. DOI: 10.1196/annals.1322.057
Source: PubMed

ABSTRACT It has been suggested that some pigments would have antioxidant properties and that their presence in dietary constituents would contribute to reduce the risk of oxidative stress-correlated diseases. Among others, inflammatory response depends on redox status and may implicate oxidative stress. Vascular endothelial cells are a direct target of oxidative stress in inflammation. We have tested the impact of the free radical scavenger and antioxidant properties of betalains from the prickle pear in an in vitro model of endothelial cells. Here we show the capacity of betalains to protect endothelium from cytokine-induced redox state alteration, through ICAM-1 inhibition.

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