Critchley, al. Activity in the human brain predicting differential heart rate responses to emotional facial expressions. Neuroimage24, 751-762

Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, London WC1N 3BG, UK.
NeuroImage (Impact Factor: 6.36). 03/2005; 24(3):751-62. DOI: 10.1016/j.neuroimage.2004.10.013
Source: PubMed

ABSTRACT The James-Lange theory of emotion proposes that automatically generated bodily reactions not only color subjective emotional experience of stimuli, but also necessitate a mechanism by which these bodily reactions are differentially generated to reflect stimulus quality. To examine this putative mechanism, we simultaneously measured brain activity and heart rate to identify regions where neural activity predicted the magnitude of heart rate responses to emotional facial expressions. Using a forewarned reaction time task, we showed that orienting heart rate acceleration to emotional face stimuli was modulated as a function of the emotion depicted. The magnitude of evoked heart rate increase, both across the stimulus set and within each emotion category, was predicted by level of activity within a matrix of interconnected brain regions, including amygdala, insula, anterior cingulate, and brainstem. We suggest that these regions provide a substrate for translating visual perception of emotional facial expression into differential cardiac responses and thereby represent an interface for selective generation of visceral reactions that contribute to the embodied component of emotional reaction.

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    • "As a result of this, engaging in FtF communication is more exciting and physiologically arousing because of the social interaction with other humans. The cues transmitted in more natural media such as facial expressions and body language elicit physiological arousal (Byron, 2008; Critchley et al., 2005). By comparison, less natural media are perceived as less exciting, duller, and less arousing (Kock, 2005b). "
    Computers in Human Behavior 01/2016; 54:1-9. DOI:10.1016/j.chb.2015.07.036 · 2.69 Impact Factor
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    • "Activation of the amygdala was also reduced in heavy marijuana users compared to controls—an effect observed for both negative and positive words . Along with the insula , the amygdala is part of a network involved in translating interoceptive responses to emotional stimuli into emotional experience ( Critchley et al . , 2005 ) . Blunted amygdala response has been observed in individuals with difficulties experiencing and processing emotions ( van der Velde et al . , 2013 ) . Acutely , cannabidiol , a psychoactive component of cannabis , has been shown to decrease amygdala activation to anxiety - inducing emotional stimuli ; this effect was further associate"
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    ABSTRACT: This work investigated the impact of heavy marijuana use during adolescence on emotional functioning, as well as the brain functional mediators of this effect. Participants (n = 40) were recruited from the Michigan Longitudinal Study (MLS). Data on marijuana use were collected prospectively beginning in childhood as part of the MLS. Participants were classified as heavy marijuana users (n = 20) or controls with minimal marijuana use. Two facets of emotional functioning—negative emotionality and resiliency (a self-regulatory mechanism)—were assessed as part of the MLS at three time points: mean age 13.4; mean age 19.6; and mean age 23.1. Functional neuroimaging data during an emotion-arousal word task were collected at mean age 20.2. Negative emotionality decreased and resiliency increased across the three time points in controls but not heavy marijuana users. Compared with controls, heavy marijuana users had less activation to negative words in temporal, prefrontal, and occipital cortices, insula, and amygdala. Activation of dorsolateral prefrontal cortex to negative words mediated an association between marijuana group and later negative emotionality. Activation of the cuneus/lingual gyrus mediated an association between marijuana group and later resiliency. Results support growing evidence that heavy marijuana use during adolescence affects later emotional outcomes.
    Developmental Cognitive Neuroscience 09/2015; DOI:10.1016/j.dcn.2015.09.003 · 3.83 Impact Factor
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    • "visual, auditory, proprioceptive and vestibular), as well as efferent copy signals from motor structures, are integrated in the PPC (Andersen et al., 1997). As for the enhanced activity of the insular cortex in the Pe component, we may note that it was reported by several fMRI studies (Menon et al., 2001; Ullsperger and von Cramon, 2001; Mathalon et al., 2003; Critchley et al., 2005a,b; Debener et al., 2005; Matthews et al., 2005; Polli et al., 2005; Ramautar et al., 2006; Klein et al., 2007), while only a recent ERP study (Dhar et al., 2011) was able to localized this area as the Pe generator. However, probably due to a sample smaller than the present one, or to the difficulty to measure the activity of a deep region with the surface EEG, the authors localized the main generator of the Pe in the posterior insula. "
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    ABSTRACT: The event-related potential (ERP) literature described two error-related brain activities: the error-related negativity (Ne/ERN) and the error positivity (Pe), peaking immediately after the erroneous response. ERP studies on error processing adopted a response-locked approach, thus, the question about the activities preceding the error is still open. In the present study, we tested the hypothesis that the activities preceding the false alarms (FA) are different from those occurring in the correct (responded or inhibited) trials. To this aim, we studied a sample of 36 Go/No-go performers, adopting a stimulus-locked segmentation also including the pre-motor brain activities. Present results showed that neither pre-stimulus nor perceptual activities explain why we commit FA. In contrast, we observed condition-related differences in two pre-response components: the fronto-central N2 and the prefrontal positivity (pP), respectively peaking at 250ms and 310ms after the stimulus onset. The N2 amplitude of FA was identical to that recorded in No-go trials, and larger than Hits. Because the new findings challenge the previous interpretations on the N2, a new perspective is discussed. On the other hand, the pP in the FA trials was larger than No-go and smaller than Go, suggesting an erroneous processing at the stimulus-response mapping level: because this stage triggers the response execution, we concluded that the neural processes underlying the pP were mainly responsible for the subsequent error commission. Finally, sLORETA source analyses of the post-error potentials extended previous findings indicating, for the first time in the ERP literature, the right anterior insula as Pe generator. Copyright © 2015. Published by Elsevier Inc.
    NeuroImage 03/2015; 113. DOI:10.1016/j.neuroimage.2015.03.040 · 6.36 Impact Factor
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