Deviance-related electrophysiological activity in mice: Is there mismatch negativity in mice?

Lomonosov Moscow State University, Moskva, Moscow, Russia
Clinical Neurophysiology (Impact Factor: 2.98). 03/2005; 116(2):353-63. DOI: 10.1016/j.clinph.2004.08.015
Source: PubMed

ABSTRACT Mismatch negativity (MMN) is an auditory event-related potential (ERP) that provides an index of auditory sensory memory and has become an important tool to investigate auditory sensory memory in cognitive neuroscience and disorders such as schizophrenia and dyslexia. The development of a mouse model of human MMN would permit to investigate the molecular biology of normal and dysfunctional MMN generation. However, the presence of MMN-like electrophysiological activity in mice has not been demonstrated.
Deviance-related ERPs were recorded in awake mice using 3 frequency deviance paradigms and one duration deviance paradigm. These paradigms were modelled after paradigms used in human studies to characterize MMN.
Significant deviance-related activity was observed in all paradigms. However, in all frequency deviance paradigms this activity manifested as an enhancement of similar activity to the standard due to differences in stimulation rate between deviant and standard stimuli rather than qualitatively different MMN-like activity. In the duration deviance paradigm negative deflections were observed that showed characteristics typical of human MMN.
MMN-like activity can be observed in mice in duration deviance paradigms. In frequency deviance paradigms effects of different stimulation rates of deviant and standard stimuli seem to be the main determinants of deviance-related activity.
Investigations of MMN-like ERPs in mice may permit to investigate the molecular basis for normal and abnormal MMN generation in neuropsychiatric disorders and dyslexia.

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    • "More direct analogs of human MMN have been observed through the measurement of scalp-recorded, epidural, and multi-unit potentials in different animal species, e.g. in the monkey (Javitt et al., 1992; Javitt et al., 1994), in the cat (Csepe et al., 1987; Pincze et al., 2001; 2002), in the guinea pig (Kraus et al., 1994), and in the mouse (Umbricht et al., 2005). Javitt et al. (1994) reported an increase in intracortical activity in the primary auditory cortex of the monkey in response to intensity deviants at a latency range of 15–60 ms whereas the onset of the surface MMN started not earlier than 60 ms. "
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    ABSTRACT: The fast detection of novel or deviant stimuli is a striking property of the auditory processing which reflects basic organizational principles of the auditory system and at the same time is of high practical significance. In human electrophysiology, deviance detection has been related to the occurrence of the mismatch negativity (MMN)--a component of the event-related potential (ERP) evoked 100 to 250 ms after the occurrence of a rare irregular sound. Recently, it has been shown in animal studies that a considerable portion of neurons in the auditory pathway exhibits a property called stimulus-specific adaptation enabling them to encode inter-sound relationships and to discharge at higher rates to rare changes in the acoustic stimulation. These neural responses have been linked to the deviant-evoked potential measured at the human scalp, but such responses occur at lower levels anatomically (e.g. the primary auditory cortex as well as the inferior colliculi) and are elicited earlier (20-30 ms after sound onset) in comparison to MMN. Further, they are not considerable enough in size to be interpreted as a direct neural correlate of the MMN. We review here a series of recent findings that provides a first step toward filling this gap between animal and human recordings by showing that comparably early modulations due to a sound's deviancy can be observed in humans, particularly in the middle-latency portion of the ERP within the first 50 ms after sound onset. The existence of those early indices of deviance detection preceding the well-studied MMN component strongly supports the idea that the encoding of regularities and the detection of violations is a basic principle of human auditory processing acting on multiple levels. This sustains the notion of a hierarchically organized novelty and deviance detection system in the human auditory system.
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    • "Several laboratories have provided ample evidence to suggest that ERP components, including a late positivity, can be obtained from mice (see Ehlers and Somes, 2002; Siegel et al., 2003; Umbricht et al., 2005). Like most ERP studies using rodents as subjects a " passive " auditory oddball paradigm has been used to generate ERPs in mice. "
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    • "The approach we introduce here circumvents these limitations, since MMN mainly involves pre-attentive processes, and imply only very elementary sensory memory processes (see Schröger, 2007, for a review). As a MMN has been observed in several species, including monkeys (Javitt, Schroeder, Steinschneider , Arezzo, & Vaughan, 1992), rats (Eriksson & Villa, 2005; Ruusuvirta et al., 1998), guinea pigs (McGee et al., 2001), mouse (Umbricht et al., 2005) etc. . . (see Näätänen et al., 2007), those first data pave the way for the possibility to estimate, under the very same conditions and without attentional confounds, time discrimination threshold in different species to precise the phylogenetic evolution of time processing. "
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