Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum.

Ghent University, Faculty of Pharmaceutical Sciences, Laboratory of Pharmacognosy and Phytochemistry, Harelbekestraat 72, B-9000 Ghent, Belgium.
Fitoterapia (Impact Factor: 2.23). 02/2005; 76(1):35-40. DOI: 10.1016/j.fitote.2004.10.002
Source: PubMed

ABSTRACT The estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum and five fractions obtained by solid-phase extraction were investigated using estrogen-responsive bioassays, a yeast cell assay and the Ishikawa Var-I assay. The extract was found to exhibit significant estrogenic activity in both assays. Furthermore, bioassay-guided fractionation led to localisation of the estrogenicity in the relatively non-polar fractions of the polyphenolic extract.

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