Article

Voltage-gated ion channels.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Current Biology (Impact Factor: 9.49). 02/2005; 15(2):R44-7. DOI: 10.1016/j.cub.2004.12.050
Source: PubMed
0 Bookmarks
 · 
264 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Despite the complexity of ion-channels, MD simulations based on realistic all-atom models have become a powerful technique for providing accurate descriptions of the structure and dynamics of these systems, complementing and reinforcing experimental work. Successful multidisciplinary collaborations, progress in the experimental determination of three-dimensional structures of membrane proteins together with new algorithms for molecular simulations and the increasing speed and availability of supercomputers, have made possible a considerable progress in this area of biophysics. This review aims at highlighting some of the work in the area of potassium channels and molecular dynamics simulations where numerous fundamental questions about the structure, function, folding and dynamics of these systems remain as yet unresolved challenges.
    Central European Journal of Chemistry 5(3):635-671. · 1.17 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We report the existence of phase-coupled oscillations in a model neural system.Themodel consists of a group of excitatory pyramidal cells in interaction with local inhibitory interneurons.The voltages across the membranes of excitatory cells are governed primarily by calcium and potassium ion conductivities. The number of potassium channels open at any given instant changes in accordance with a deterministic law.The time scale of this change is set by a constant which depends onmidpoint potentials at which potassium and calcium currents are half-activated. The growth of mean membrane potential of excitatory principal cells is controlled by that of the inhibitory interneurons. Nonlinear oscillatory system associated with these limit cycles starting from two different initial conditions maintain a definite phase relationship. The phase-coupled oscillations in electrical activity of the neuronal cells carry together amplitude, phase, and time information for cellular signaling. This mechanism supports an energy efficient way of information processing in the central nervous system. The information content is encoded as persistent periodic oscillations represented by stable limit cycles in the phase space.
    ISRN Biomathematics 01/2013;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We have discovered a limit cycle with characteristic signature of chaos; i. e., sensitive dependence on initial conditions. These limit cycles are information carriers which preserve phase information.
    International Journal of Biomathematics 01/2013; · 0.63 Impact Factor

Full-text (2 Sources)

Download
22 Downloads
Available from
Jun 5, 2014