Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy

Department of Allergy, Satou Hospital, Hirakata City, Osaka Prefecture 573-1124, Japan.
Life Sciences (Impact Factor: 2.7). 03/2005; 76(13):1527-32. DOI: 10.1016/j.lfs.2004.10.028
Source: PubMed


Effect of cholesterol on in vitro latex-specific IgE production by mononuclear cells from atopic dermatitis patients with latex allergy. Cholesterol enhanced latex-specific IgE production in a dose-dependent fashion, and maximal enhancement was achieved at 1 microg/ml. In contrast, cholesterol had no effect on latex -specific IgA or IgG4 production. Study for cytokine production revealed that cholesterol decreased latex-induced production of IFN-gamma and IL-12, while it increased latex-induced production of IL-4, IL-10 and IL-13. These results indicate that cholesterol skews cytokine pattern toward Th2 type. Collectively, cholesterol may increase allergen-specific IgE production, which may in turn aggravate allergic symptoms.

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