Systematic review of the Sugarbaker procedure for pseudomyxoma peritonei

Southampton Health Technology Assessments Centre, Wessex Institute for Health Research and Development, University of Southampton, Southampton, UK.
British Journal of Surgery (Impact Factor: 5.54). 02/2005; 92(2):153-8. DOI: 10.1002/bjs.4862
Source: PubMed


Pseudomyxoma peritonei, a rare progressive disease process within the peritoneum, is characterized by an abundance of mucinous fluid; if left untreated, the condition is fatal. The aim of this article is to assess the clinical effectiveness and costs of the Sugarbaker procedure for pseudomyxoma peritonei.
A systematic review of the literature up to April 2004 was undertaken, with modelling of costs.
Five retrospective case-series reports met the inclusion criteria. Survival after operation was approximately 95 per cent at 2 years and 60-68 per cent at 10 years, with 41-52 per cent of patients having no evidence of disease at the end of follow-up. A Monte Carlo simulation model estimated the marginal cost for one patient over a maximum of 5 years to be about pound 9700 (standard deviation pound 1300).
Evidence of the effectiveness of the Sugarbaker procedure for pseudomyxoma peritonei is limited in quantity and quality, but suggests there may be some benefit for patients. The marginal cost of the operation is about pound 9700, provided that trained and experienced staff are available to perform the procedure.

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Available from: Peter Davidson, Jul 28, 2014
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    • "Pseudomyxoma peritonei is a disorder with low malignant potential, originates from the appendix and ovaries and spreads to the abdominal cavity causing mucinous ascites.[1] This condition is treated by cytoreduction and in recent times by the addition of hyperthermic intraperitoneal chemotherapy (HIPEC). "
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    ABSTRACT: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy plays a considerable role as a treatment modality in surgical oncology in western countries. The advantage of this procedure is that the heated chemotherapeutic agent is circulated in the abdominal cavity and achieves high peritoneal concentration with limited systemic absorption. This procedure is complex not only to the surgical team, but also to the anaesthetist because apart from managing the usual physiologic changes associated with major surgery, one should also be prepared to manage the physiologic changes during the hyperthermic phase. Here, we present our experience with our first case.
    Indian journal of anaesthesia 04/2014; 58(1):59-62. DOI:10.4103/0019-5049.126799
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    • "The term PMP has been applied broadly and includes a heterogeneous group of pathological lesions from the benign to the borderline to the frankly malignant lesion.3,4 Ronnett et al have suggested a classification based on tumor pathology in which they place all PMP in three groups in order of decreasing prognosis: disseminated peritoneal adenomucinosis, peritoneal mucinous carcinoma with intermediate or discordant features, and peritoneal mucinous carcinoma.4 "
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    ABSTRACT: Pseudomyxoma peritonei is an uncommon condition with an estimated incidence of one to two per million (worldwide) per year. It is characterized by the peritoneal deposition of mucinous tumors, most commonly of the appendix, and occasionally from the ovary, coupled by mucinous ascites. We report the case of a 76-year-old woman who presented with increased abdominal girth and dyspnea for 2 weeks. She was diagnosed as a case of pseudomyxoma peritonei. She was submitted to right oophorectomy, omentectomy, and pseudomyxoma debulking. The histology was compatible with a mucinous tumor of colorectal/appendicular origin. Chemotherapy was not administered because of her functional status. Two years and 8 months later, she refers with postprandial fullness and has moderate ascites.
    International Journal of General Medicine 03/2014; 7:137-41. DOI:10.2147/IJGM.S51504
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    • "Pseudomyxoma peritonei (PMP) is a poorly understood condition affecting both sexes equally, with an increasing incidence with age.[1] It is characterized by progressive intraperitoneal mucinous tumor and ascites. "
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    ABSTRACT: Pseudomyxoma peritonei is a rare progressive disease. Patients commonly present with a picture of acute appendicitis or with increasing abdominal girth. We present a case of a 71 year old man who presented with right iliac fossa pain, fever and vomiting. His abdominal examination revealed right iliac fossa mass which was confirmed radiologically. Diagnostic laparoscopy showed jelly like material along with a right iliac fossa mass. The aspirate was negative for malignancy initially. Due to persistance and progression of his disease he underwent right hemicolectomy. Histopathological diagnosis showed moderately differentiated adenocarcinoma of the cecum Duke's C2.
    05/2010; 17(2):103-6. DOI:10.4103/1319-1683.71993
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