Angiotension-converting enzyme gene I/D polymorphism in patients with angina and normal coronary arteriograms.

{ "0" : "Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK" , "1" : "University College London Centre for Cardiovascular Genetics, Rayne Institute, London, UK" , "3" : "Angiotensin I-converting enzyme genotype" , "4" : "Fatigue"}
International Journal of Cardiology (Impact Factor: 6.18). 03/2005; 98(2):339-40. DOI: 10.1016/j.ijcard.2003.10.049
Source: PubMed

ABSTRACT A polymorphism of the human angiotensin-converting enzyme (ACE) gene has been identified in which the insertion (I) rather than the deletion (D) variant is associated with lower circulating and tissue ACE activity. ACE I allele is associated with resistance and endurance performance. Skeletal muscle metabolic efficiency is reduced in patients with heart failure and is improved by ACE inhibition. Profound muscle fatigue is a predominant and debilitating symptom in a proportion or patients with angina and normal coronary arteriograms (ANCA), and we postulated that the gene D allele might be associated with the presence of fatigue in ANCA patients. We studied 33 consecutive patients with typical ANCA who completed a validated fatigue questionnaire, and found an excess of the D allele frequency in patients with the highest fatigue scores compared to those with the lowest (64% vs. 36%; p=0.027).

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