GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Nature Reviews Molecular Cell Biology (Impact Factor: 37.81). 03/2005; 6(2):167-80. DOI: 10.1038/nrm1587
Source: PubMed


Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.

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    • "The marker linked to ATP1A1 has been identified as outlier gene in multiple stickleback saltwater–freshwater transitions worldwide (Jones et al. 2006, 2012a,b; McCairns and Bernatchez 2010; DeFaveri et al. 2011; Shimada et al. 2011). A major outlier in our study was marker Stn46, which is linked to the gene for Rho guanine nucleotide exchange factor 9. It is a member of the gene family coding for rho proteins, a subfamily of the guanine nucleotide exchange factors (GEFs), which are multidomain proteins involved in the activation of small GTPases (Rossman et al. 2005). The Rho family is involved in relaying signals from cell-surface receptors to the actin cytoskeleton and elsewhere (Dvorsky and Ahmadian 2004). "
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