CAY-1, a novel antifungal compound from cayenne pepper.

MycoLogics, Inc., Aurora, Colorado 80010, USA.
Medical Mycology (Impact Factor: 2.26). 03/2003; 41(1):75-81.
Source: PubMed

ABSTRACT CAY-1, a novel saponin from Capsicum frutescens (commercially known as cayenne pepper) was investigated to determine its in vitro antifungal activity, mechanism of action and mammalian cell cytotoxicity. CAY-1 was active against 16 different fungal strains, including Candida spp. and Aspergillus fumigatus [minimum inhibitory concentrations (MIC) ranging from 4 to 16 microg ml(-1)], and was especially active against Cryptococcus neoformans (90% inhibition at 1 microg ml(-1)). Synergistic activity was also observed between CAY-1 and amphotericin B against Candida albicans and A. fumigatus. No significant cytotoxicity was demonstrated when CAY-1 was tested against 55 mammalian cell lines at up to 100 microg ml(-1). Importantly, CAY-1 appears to act by disrupting the membrane integrity of fungal cells.

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    ABSTRACT: Candida albicans is one of the main causes of vaginitis, especially in women with recurrent episodes. The appearance of drug resistant C. albicans and adverse effects of chemical agents have raised interest in Echinophora platyloba as one of four native species in Traditional Persian-Iranian medicine. This study evaluates the antifungal activity of ethanolic extract from dried aerial parts of E. platyloba against 27 clinical isolates of C. albicans from women suffering chronic recurrent vaginitis by micro-broth dilution assay. The synergistic effect of azole drugs and E. platyloba ethanolic extract were also determined by disc diffusion method after determining the MIC90. The results of this study showed a potent synergistic effect of E. platyloba ethanolic extract and itraconazole (P<0.01) and fluconazole (P<0.001) but an antagonistic effect between E. platyloba ethanolic extract and clotrimazole and miconazole against clinical isolates of C. albicans. These results must be confirmed by clinical application and by further clinical studies.
    Journal de Mycologie Médicale/Journal of Medical Mycology 04/2014; · 0.40 Impact Factor
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    ABSTRACT: Introduction: With the increasing use of medicinal plants in medical treatment, this branch of alternative medicine, has found a special place in the treatment of diseases. Some people use plants in traditional medicine, but has not been considered appropriate that one of these is platyloba or Echinophora platyloba. According to the traditional use of this plant in order to prevent mildew food, we decided to determine the inhibitory effect of extract of Echinophora platyloba against some of the Dermatophytes. Methods: Of plants arranged in the growing season, the percolation method was used to extract so that the zero concentration in mg per ml is as a control and the concentrations of 35, 50, 150 and 250 mg per ml were collected. The fungi were then cultured (by Agar Dilution Method), in the vicinity of the above concentrations and were observed after 21 days of culture, and the results were recorded. RESULTS: RESULTS: All fungi grew in the control tube. T. verrucosum and T. schoenleinii were sensitive and did not grow at all dilutions. Trichophyton rubrum and Microsporum gypseum were resistant in all dilutions and grow. Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum were sensitive only at concentrations of 250 mg per ml dilutions and were resistant to others. T. violaseum, was resistant at concentrations of 35 and 50, but with the increasing concentration to 150 and 250 mg per ml was sensitive. Conclusion: According to the prepared concentrations, dilution of 35, 50 and 150 mg per mL have effect and practical applications. Therefore, the plant can be properly used in mentioned concentration against Dermatophytes Trichophyton verrucosum Schonlein and. Trichophyton mentagrophytes in Microsporum canis and Epidermophyton floccosum effectiveness is depending on the patient situation and the severity of the infection. But the extract may not be used against Trichophyton mentagrophytes and Microsporum gypseum. Keywords: Echinophora platyloba, extract, dermatophytes,
    Journal of Midicinal Plants. 01/2006; 2(18):10-16.
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    ABSTRACT: Objectif Candida albicans est l’une des principales causes de vaginite, en particulier dans les formes chroniques et récidivantes. L’apparition des souches résistantes de C. albicans et les effets indésirables des traitements chimiques ont suscité un intérêt pour Echinophora platyloba, l’une des quatre espèces indigènes utilisées en médecine traditionnelle persane-iranienne. Matériel et méthodes Cette étude évalue l’activité antifongique de l’extrait éthanolique de parties aériennes séchées de E. platyloba contre 27 isolats cliniques de C. albicans de femmes souffrant de vaginite chronique récurrente par un test de micro-dilution en milieu liquide. L’effet synergique entre les médicaments azolés et l’extrait éthanolique de E. platyloba a également été étudié par la méthode de diffusion des disques après détermination de la CMI90. Résultats Les résultats de cette étude ont montré un effet synergique puissant entre l’extrait éthanolique de E. platyloba et l’itraconazole (p < 0,01) et le fluconazole (p < 0,001), mais un effet antagoniste avec le clotrimazole et le miconazole contre les isolats cliniques de C. albicans. Conclusion Ces résultats doivent être confirmés par l’utilisation clinique et par des études cliniques complémentaires.
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