Osteoblastoma of the mandible: systematic review of the literature and report of a case.
ABSTRACT Benign osteoblastoma is a bone tumour that seldom occurs in the facial bones. The objective of this article is to add one more case of this rare lesion to the academic literature and to provide a systematic review of previously published cases. A new case of benign osteoblastoma is presented and clinical, radiographic and microscopic aspects, as well as differential diagnosis, treatment and follow-up are discussed. The importance of the correct diagnosis of this type of lesion is stressed, since it presents a clinical, radiographic and microscopic similarity to other bone lesions, including malignant tumours, which may lead the professional into conducting the case in an improper manner.
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ABSTRACT: Background: Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tu-mors. Aim: The purpose of this report is to present an osteoblastoma of the mandible, with particular emphasis on the differential diagnosis of this rare tu-mor. Methods-Results: the lesion showed osteoblast-like cells, stromal cells, osteoclast-like cells and inter-lacing trabeculae of osteoid. Because of the high cel-lularity of the tumor, immunohistochemical analysis was performed using the cell proliferation marker Ki-67, the p53 and the anti-apoptotic protein Bcl-2. The lesion demonstrated low to moderate prolifera-tive activity and no immunoreactivity was detected for p53. An interesting finding was the Bcl-2 expres-sion by the multinucleated osteoclast-like giant cells, in contrast to the lack of Bcl-2 expression from osteo-blast-like and stromal tumor cells. Conclusions: To our knowledge the Bcl-2 expression has not yet been in-vestigated in benign or malignant osteoblastic tumors. This finding may be related to the molecular mecha-nisms regulating the apoptosis of osteoclast-like tu-mor cells or their function.Open Journal of Stomatology 05/2010; 01(04). DOI:10.4236/ojst.2011.14032
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ABSTRACT: Benign osteoblastoma refers to a benign tumor of the bone. Osteoblastoma most commonly affects the vertebrae and long tubular bones, however, in rare cases is observed in the facial bones. The current study presents the case of a 12-year-old female patient with a tumor in the mandibular body. Radiological imaging revealed a lesion with regular contours. The lesion was radically resected and histological analysis of the specimen demonstrated features that are typical of a benign osteoblastoma. The consequential defects of the jaw were reconstructed using titanium implants and autologous bone transplantation. The patient remains disease free subsequent to a five-month follow-up period. The aim of the present report is to present a rare case of benign osteoblastoma of the mandible. This study demonstrated that correct diagnosis and complete surgical excision are important to reduce the risk of recurrence of a benign osteoblastoma.Oncology letters 12/2014; 8(6):2691-2694. DOI:10.3892/ol.2014.2593 · 0.99 Impact Factor
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ABSTRACT: Over the past decade, there have been remarkable advances in bone tumor pathology. Insights into the genetic basis and pathobiology of many tumor types have impacted diagnosis, classification, and treatment. However, because gnathic lesions may comprise only a small proportion of cases overall for many tumors, clinicopathologic features and management considerations specific to this subset may be overlooked. Here we provide a summary of recent developments in the following tumor types: osteosarcoma (OS), chondrosarcoma (CS), osteoid osteoma (OO), osteoblastoma (OB), and Ewing sarcoma (ES). In particular, we will give special consideration to cases arising in the jaws.Head and Neck Pathology 11/2014; DOI:10.1007/s12105-014-0587-8