Osteoblastoma of the mandible: Systematic review of the literature and report of a case

Instituto Lauro de Souza Lima, Бауру, São Paulo, Brazil
Dentomaxillofacial Radiology (Impact Factor: 1.39). 02/2005; 34(1):1-8. DOI: 10.1259/dmfr/24385194
Source: PubMed


Benign osteoblastoma is a bone tumour that seldom occurs in the facial bones. The objective of this article is to add one more case of this rare lesion to the academic literature and to provide a systematic review of previously published cases. A new case of benign osteoblastoma is presented and clinical, radiographic and microscopic aspects, as well as differential diagnosis, treatment and follow-up are discussed. The importance of the correct diagnosis of this type of lesion is stressed, since it presents a clinical, radiographic and microscopic similarity to other bone lesions, including malignant tumours, which may lead the professional into conducting the case in an improper manner.

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    • "However, pain and swelling, which are the main presenting features were absent in our case. Radiographically, the lesion may often have a soft tissue capsule around the periphery indicating that the tumor is more mature in the centre and the internal structure is more radiolucent as compared to osteoma.17 Histopathologically, the presence of multinucleated giant cells and more vascularisation helps to differentiate it from an osteoma.15,16 "
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    ABSTRACT: Osteoma is a dense bony proliferation of otherwise normal membranous bone. This tumor is essentially restricted to the craniofacial skeleton and is rarely diagnosed in other bones. The mandible and the paranasal sinuses are the most common sites, while the involvement of the coronoid process has been reported in only 6 cases so far. This report demonstrated a case of osteoma occurring at the mandibular coronoid process in a 26-year-old female patient. The patient was managed with surgical resection of the osteoma followed by physiotherapy.
    Imaging Science in Dentistry 03/2013; 43(1):45-8. DOI:10.5624/isd.2013.43.1.45
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    • "In 1956, the lesion was definitely separated from osteoid osteoma and recognized as an entity by Jaffe and Lichtenstein, in separate reports, under the name of benign osteoblastoma. This is the name that has been adopted by the World Health Organization Classification of Bone Tumors and the Armed Forces Institute of Pathology.[7] "
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    ABSTRACT: The clinical facts and radiologic findings are very important in the diagnostic evaluation of jaw swellings, and must be considered along with histologic findings. Osteoblastoma, an uncommon primary lesion of the bone that occasionally arises in the jaws, is one such lesion causing a localized jaw swelling. Clinically, osteoblastoma can be symptomatic or even remain symptom-free, and may be diagnosed only on routine radiographic examination. Histologically and clinically, differential diagnosis for osteoblastoma ranges from a variety of benign and malignant tumors that poses a diagnostic dilemma. Stressing the importance of the correct diagnosis of such lesions, this report discusses a case of aggressive osteoblastoma of the mandible posing as a diagnostic dilemma.
    Dental research journal 05/2012; 9(3):334-7.
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    • "Osteoblastoma usually appears in the second decade of life as a painful expansion of the bone cortex with non specific radiographic appearance . Histologically, it is characterized by osteoblastlike cells proliferation forming trabeculae of osteoid and immature bone in a highly vascularized stroma [2] [3] [4] [5] [6]. These cells are usually uniform in the benign or " classical " osteoblastoma, but they may exhibit nuclear hyperchromatism or/and pleomorphism with features of epithelioid appearance in the " atypical type " of osteoblastoma [5] [7]. "
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    ABSTRACT: Background: Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tu-mors. Aim: The purpose of this report is to present an osteoblastoma of the mandible, with particular emphasis on the differential diagnosis of this rare tu-mor. Methods-Results: the lesion showed osteoblast-like cells, stromal cells, osteoclast-like cells and inter-lacing trabeculae of osteoid. Because of the high cel-lularity of the tumor, immunohistochemical analysis was performed using the cell proliferation marker Ki-67, the p53 and the anti-apoptotic protein Bcl-2. The lesion demonstrated low to moderate prolifera-tive activity and no immunoreactivity was detected for p53. An interesting finding was the Bcl-2 expres-sion by the multinucleated osteoclast-like giant cells, in contrast to the lack of Bcl-2 expression from osteo-blast-like and stromal tumor cells. Conclusions: To our knowledge the Bcl-2 expression has not yet been in-vestigated in benign or malignant osteoblastic tumors. This finding may be related to the molecular mecha-nisms regulating the apoptosis of osteoclast-like tu-mor cells or their function.
    Open Journal of Stomatology 05/2010; 01(04). DOI:10.4236/ojst.2011.14032
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