Article
Electrochemical approach of anticancer drugs--DNA interaction.
Bioprocess Technology Division, National Institute for Biotechnology and Genetic Engineering, P.O. Box 577, Jhang Road, Faisalabad, Pakistan.
Journal of Pharmaceutical and Biomedical Analysis (impact factor:
2.97).
03/2005;
37(2):205-17.
DOI:10.1016/j.jpba.2004.10.037
pp.205-17
Source: PubMed
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Citations (0)
- Cited In (7)
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Article: Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA
Marmara Pharmaceutical Journal. 01/2012; 16(1):48-55. -
Chapter: Electrochemical DNA Biosensors – Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review)
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ABSTRACT: Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between studied analytes and DNA. Observing the pre-and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review should provide evidence that the electrochemical approach brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between organic xenobiotic compounds and DNA.12/2012: pages 141-162; , ISBN: 978-80-7395-563-2 (printed), 978-80-7395-564-9 (on-line) -
Article: Drug-DNA interactions and their study by UV-Visible, fluorescence spectroscopies and cyclic voltametry.
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ABSTRACT: The present paper review the drug-DNA interactions, their types and applications of experimental techniques used to study interactions between DNA and small ligand molecules that are potentially of pharmaceutical interest. DNA has been known to be the cellular target for many cytotoxic anticancer agents for several decades. Understanding how drug molecules interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. In this review article, we attempt to bring together topics that cover the breadth of this large area of research. The interaction of drugs with DNA is a significant feature in pharmacology and plays a vital role in the determination of the mechanisms of drug action and designing of more efficient and specifically targeted drugs with lesser side effects. Several instrumental techniques are used to study such interactions. In the present review, we will discuss UV-Visible spectroscopy, fluorescence spectroscopy and cyclic voltammetry. The applications of spectroscopic techniques are reviewed and we have discussed the type of information (qualitative or quantitative) that can be obtained from the use of each technique. Not only have novel techniques been applied to study drug-DNA interactions but such interactions may also be the basis for the development of new assays. The interaction between DNA and drugs can cause chemical and conformational modifications and, thus, variation of the electrochemical properties of nucleobases.Journal of photochemistry and photobiology. B, Biology 04/2013; 124C:1-19. · 1.87 Impact Factor
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Keywords
anticancer drugs
aspects
biological studies
drug discovery
drug interaction
drugs
Electrochemical approach
electrochemical investigation
good evidence
growing interest
new drugs
pharmaceutical development processes
post electrochemical signals
rational drug design
recent years
