Steroid dementia: An overlooked diagnosis?
ABSTRACT The authors studied a 72-year-old man with polymyalgia rheumatica who, after taking 100 mg of prednisone for 3 months, developed a psychosis followed by dementia. It was initially considered that the dementia was a separate neurodegenerative condition, probably of Alzheimer type, but when steroids were discontinued, he rapidly returned to his previous level of functioning. Reviewing the literature regarding the effects of steroids on cerebral function, the authors found that such cases of "reversible dementia" are not uncommon, although rarely given the emphasis they deserve. The authors believe, given the extensive use of steroids in medical practice, that physicians should be more aware of this important cause of reversible dementia.
Article: A case of steroid- induced mania[Show abstract] [Hide abstract]
ABSTRACT: Corticosteroids, used in the treatment of many illnesses, mainly autoimmune diseases, have various side effects. Although pathophysiology of psychiatric side effects are still controversial, there are different risk factors identified in this regard. Priority in the treatment of corticosteroid induced mania is to cut off steroids. As only mood stabiliz-er can be used, neuroleptic/mood stabilizer combinations also can be used in the treatment. In our case who had peripheral facial paralysis, corticosteroid induced mania with psychotic symptoms is aimed to discuss in terms of risk factors, response to olanzapine and treatment course.06/2013; 3(2):74-76. DOI:10.5455/jmood.20130114092424
Article: Methotrexate Neurotoxicity Causes Speech Problem Severe, Irreversible Sensory Neuropathy Due to Long-Term Use of Linezolid Hypomania with Topiramate Bortezomib-Induced Hepatitis Steroid Dementia - An Overlooked Diagnosis? Promethazine Warning Medication Discrepancies at the Time of Hospital Admission Medication-Induced Intracranial Hypertension
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ABSTRACT: BACKGROUND: Evidence for a relationship between hospitalization and incident cognitive decline exists mainly in the literature focusing on critical care hospitalization. Recent studies, however, have also found an association between noncritical care hospitalization and the development of cognitive decline. OBJECTIVE: This article will review the literature pertaining to hospitalization and cognitive decline, including hospitalizations for both critical and noncritical care, and in medical and surgical patients. The article will also explore the various factors that have been implicated in the development of cognitive decline and dementia. METHODS: Review of the literature was completed using PubMed and Medline search programs. Results: Several articles supporting evidence for the association between hospitalization and cognitive decline are available. Evidence for potential mediating factors also does exist. CONCLUSIONS: There is evidence to support an association between hospitalization and development of cognitive decline. Factors that could mediate this association include, but may not be limited to, delirium, medications, stress, and depression. There is a need for further research in this area in order to better understand the underlying pathophysiology involved in the development of cognitive decline and dementia and to determine if preventive measures might be beneficial in decreasing risk for cognitive decline for patients who are hospitalized.The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry 02/2013; 22(5). DOI:10.1016/j.jagp.2012.08.012 · 3.52 Impact Factor