Detection of t(14;18)(q32;q21) in B-cell chronic lymphocytic leukemia.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Muenchen, Germany.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 04/2005; 129(3):410-1. DOI: 10.1043/1543-2165(2005)129<410:DOQIBC>2.0.CO;2
Source: PubMed


Cytomorphologic testing and multiparameter flow cytometry are the mainstays in diagnosing B-cell chronic lymphocytic leukemia, whereas fluorescence in situ hybridization that targets the translocation t(14;18)(q32;q21) often is used to identify follicular lymphoma. Therapy is highly diverse between both diseases. We describe a case with cytomorphologically and immunologically proven B-cell chronic lymphocytic leukemia in which t(14;18)(q32;q21) was found.

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    • "The t(14;18)(q32; q21), involving the immunoglobulin heavy chain (IGH@) locus and the B-cell CLL/lymphoma 2 (BCL2) gene, is characteristic of follicular lymphomas and is found in ~90% of cases [10]. It is unusual in CLL and is found in, at most, 1% to 2% of cases [6] [11] [12] [13] [14] [15] [16] [17]. The prognostic significance of t(14;18) in CLL is not clear. "
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