Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon.
ABSTRACT The effects of intake of dietary amounts of carrot or corresponding amounts of (-)-(3R)-falcarinol from carrots on development of azoxymethane (AOM)-induced colon preneoplastic lesions were examined in male BDIX rats. Three groups of eight AOM-treated rats were fed the standard rat feed Altromin supplemented with either 10% (w/w) freeze-dried carrots with a natural content of 35 mug falcarinol/g, 10% maize starch to which was added 35 mug falcarinol/g purified from carrots, or 10% maize starch (control). After 18 weeks, the animals were euthanized and the colon was examined for tumors and aberrant crypt foci (ACF), which were classified into four size classes. Although the number of small ACF was unaffected by the feeding treatments, the numbers of lesions as a function of increasing size class decreased significantly in the rats that received one of the two experimental treatments, as compared with the control treatment. This indicates that the dietary treatments with carrot and falcarinol delayed or retarded the development of large ACF and tumors. The present study provides a new perspective on the known epidemiological associations between high intake of carrots and reduced incidence of cancers.
SourceAvailable from: Mrunalini N. Desai[Show abstract] [Hide abstract]
ABSTRACT: The bioactive volatile compounds from plant samples are analyzed by using GC-MS technique. Plant extract of mangrove species Cynometra iripa Kostel. are analysed for bioactive compounds. Five major bioactive volatile compounds have been identified in the seeds and ten in seed coat viz. falcarinol, Butyric acid-pentadecyl ester, stigmast-4-en-3-one, Beta-sitosterol, Vitamin E cholesta-4, 6-diene-3-01, (3-beta), 3,5-di-ter-butyl-4-hydroxy benzaldehyde, 1-Eicosanol, Distearyl sulphide, 1,2-Benzenedicarboxylic acid butyl 2-ethylhexyl ester, 2,5-di-ter-butyl-1,4-benzoquinine, Squalene, Progesterone, Beta-carotene, Cholesta-4,6-diene-3-ol, (3 beta). These compounds are found to be useful as bactericides, insecticides, fungicides and anti cancerous. Cynometra iripa seeds are thus rich in volatile compounds.Journal of Universal Computer Science 01/2015; 03(03):5. · 0.40 Impact Factor
Technical Report: Health attributes of yellow/orange vegetables
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ABSTRACT: At Jõgeva Plant Breeding Institute, cultivation of the Estonian carrot variety 'Jõgeva Nantes' conventionally (with application of mineral fertilizers: N 115, P 40 and K 152 kg ha -1 and pesticides: Fenix, Actara 25 WG, Agil and Signum) and organically (compost, Humistar, agryl cover) was compared. Marketable yield of organic carrots was 11% higher than that of conventionally grown carrots. Conventional carrots contained pesticide residues and had significantly higher nitrate concentration than organic carrots. Contents of dry matter, total sugars, soluble solids, phosphorus, potassium, calcium and magnesium did not significantly differ between carrots between cultivation systems. The contents of ß-carotene, vitamin C and nitrogen were significantly lower in organically grown than in conventionally grown carrot.